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Preclinical MRI

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Cover of 'Preclinical MRI'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to MRI Physics
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    Chapter 2 Basic Pulse Sequences in Magnetic Resonance Imaging
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    Chapter 3 Dynamic Susceptibility Contrast MRI in Small Animals
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    Chapter 4 Preclinical Arterial Spin Labeling Measurement of Cerebral Blood Flow
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    Chapter 5 Dynamic Contrast-Enhanced MRI
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    Chapter 6 Diffusion-Weighted Magnetic Resonance Imaging
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    Chapter 7 Diffusion Tensor Imaging (DTI)
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    Chapter 8 Mapping Functional Connectivity in the Rodent Brain Using Electric-Stimulation fMRI
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    Chapter 9 Functional Diffusion Magnetic Resonance Imaging
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    Chapter 10 In Vivo 1 H Magnetic Resonance Spectroscopy
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    Chapter 11 In Vivo Heteronuclear Magnetic Resonance Spectroscopy
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    Chapter 12 1 H Spectroscopic Imaging of the Rodent Brain
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    Chapter 13 Susceptibility Weighted MRI in Rodents at 9.4 T
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    Chapter 14 Biomedical 19 F MRI Using Perfluorocarbons
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    Chapter 15 Rodent Abdominal Adipose Tissue Imaging by MR
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    Chapter 16 Cardiac MRI in Small Animals
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    Chapter 17 In Utero MRI of Mouse Embryos
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    Chapter 18 Oxygenation Imaging by Nuclear Magnetic Resonance Methods
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    Chapter 19 Molecular Magnetic Resonance Imaging (mMRI)
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    Chapter 20 Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer
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    Chapter 21 MRI in the Study of Animal Models of Neurodegenerative Diseases
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    Chapter 22 MRI in the Study of Animal Models of Stroke
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    Chapter 23 Assessment of Blood Brain Barrier Leakage with Gadolinium-Enhanced MRI
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    Chapter 24 In Vivo Pharmacokinetics of Magnetic Nanoparticles
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    Chapter 25 Anesthesia and Monitoring of Animals During MRI Studies
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    Chapter 26 Advanced Contrast Agents for Multimodal Biomedical Imaging Based on Nanotechnology
Attention for Chapter 20: Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer
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Chapter title
Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer
Chapter number 20
Book title
Preclinical MRI
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7531-0_20
Pubmed ID
Book ISBNs
978-1-4939-7530-3, 978-1-4939-7531-0
Authors

Menglin Cheng, Kristine Glunde, Cheng, Menglin, Glunde, Kristine

Abstract

Magnetic resonance spectroscopy (MRS) or spectroscopic imaging (MRSI) enables the detection of metabolites, amino acids, and lipids, among other biomolecules, in tumors of live mouse models of cancer. Tumor-bearing mice are anesthetized by breathing isoflurane in a magnetic resonance (MR) scanner dedicated to small animal MR. Here we describe the overall setup and steps for measuring 1H and 31P MRS and 1H MRSI of orthotopic breast tumor models in mice with surface coils. This protocol can be adapted to the use of volume coils to measure 1H and 31P MRS(I) of tumor models that grow inside the body. We address issues of animal handling, setting up the measurement, measurement options, and data analysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 25%
Researcher 2 25%
Librarian 1 13%
Student > Bachelor 1 13%
Unknown 2 25%
Readers by discipline Count As %
Psychology 1 13%
Medicine and Dentistry 1 13%
Neuroscience 1 13%
Chemistry 1 13%
Engineering 1 13%
Other 0 0%
Unknown 3 38%