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Notch signaling and ghost cell fate in the calcifying cystig odontogenic tumor

Overview of attention for article published in European Journal of Medical Research, November 2011
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3 Wikipedia pages

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17 Mendeley
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Title
Notch signaling and ghost cell fate in the calcifying cystig odontogenic tumor
Published in
European Journal of Medical Research, November 2011
DOI 10.1186/2047-783x-16-11-501
Pubmed ID
Authors

C. H. Siar, T. Kawakami, R. R. Buery, K. Nakano, M. Tomida, H. Tsujigiwa, P. P. Han, H. Nagatsuka, H. K. Ng

Abstract

Notch signaling is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates. Ghost cells (GCs) are anucleate cells with homogeneous pale eosinophilic cytoplasm and very pale to clear central areas (previous nucleus sites). Although GCs are present in a variety of odontogenic lesions notably the calcifying cystic odontogenic tumor (CCOT), their nature and process of formation remains elusive. The aim of this study was to investigate the role of Notch signaling in the cell fate specification of GCs in CCOT. Immunohistochemical staining for four Notch receptors (Notch1, Notch2, Notch3 and Notch4) and three ligands (Jagged1, Jagged2 and Delta1) was performed on archival tissues of five CCOT cases. Level of positivity was quantified as negative (0), mild (+), moderate (2+) and strong (3+). Results revealed that GCs demonstrated overexpression for Notch1 and Jagged1 suggesting that Notch1-Jagged1 signaling might serve as the main transduction mechanism in cell fate decision for GCs in CCOT. Protein localizations were largely membranous and/or cytoplasmic. Mineralized GCs also stained positive implicating that the calcification process might be associated with upregulation of these molecules. The other Notch receptors and ligands were weak to absent in GCs and tumoral epithelium. Stromal endothelium and fibroblasts were stained variably positive.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Researcher 2 12%
Student > Master 2 12%
Student > Bachelor 1 6%
Other 1 6%
Other 2 12%
Unknown 6 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 18%
Agricultural and Biological Sciences 3 18%
Medicine and Dentistry 2 12%
Environmental Science 1 6%
Unknown 8 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2021.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from European Journal of Medical Research
#230
of 923 outputs
Outputs of similar age
#52,683
of 154,848 outputs
Outputs of similar age from European Journal of Medical Research
#5
of 8 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 923 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,848 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.