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Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons

Overview of attention for article published in BMC Neuroscience, January 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

blogs
1 blog

Citations

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56 Dimensions

Readers on

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43 Mendeley
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Title
Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons
Published in
BMC Neuroscience, January 2008
DOI 10.1186/1471-2202-9-75
Pubmed ID
Authors

Wen Ji Yuan, Takao Yasuhara, Tetsuro Shingo, Kenichiro Muraoka, Takashi Agari, Masahiro Kameda, Takashi Uozumi, Naoki Tajiri, Takamasa Morimoto, Meng Jing, Tanefumi Baba, Feifei Wang, Hanbai Leung, Toshihiro Matsui, Yasuyuki Miyoshi, Isao Date

Abstract

Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-2-pyrazolin-5-one), which has already been used for the treatment of cerebral ischemia in Japan, on TH-positive dopaminergic neurons using PD model both in vitro and in vivo. 6-hydroxydopamine (6-OHDA), a neurotoxin for dopaminergic neurons, was added to cultured dopaminergic neurons derived from murine embryonal ventral mesencephalon with subsequet administration of edaravone or saline. The number of surviving TH-positive neurons and the degree of cell damage induced by free radicals were analyzed. In parallel, edaravone or saline was intravenously administered for PD model of rats receiving intrastriatal 6-OHDA lesion with subsequent behavioral and histological analyses.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Japan 1 2%
Brazil 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Student > Ph. D. Student 7 16%
Student > Postgraduate 6 14%
Student > Master 6 14%
Lecturer 3 7%
Other 12 28%
Readers by discipline Count As %
Medicine and Dentistry 17 40%
Agricultural and Biological Sciences 14 33%
Neuroscience 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Chemistry 2 5%
Other 2 5%
Unknown 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2017.
All research outputs
#1,995,115
of 9,772,430 outputs
Outputs from BMC Neuroscience
#174
of 934 outputs
Outputs of similar age
#56,669
of 254,098 outputs
Outputs of similar age from BMC Neuroscience
#2
of 16 outputs
Altmetric has tracked 9,772,430 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 934 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.