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Mendeley readers
Attention Score in Context
| Title |
Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons
|
|---|---|
| Published in |
BMC Neuroscience, August 2008
|
| DOI | 10.1186/1471-2202-9-75 |
| Pubmed ID | |
| Authors |
Wen Ji Yuan, Takao Yasuhara, Tetsuro Shingo, Kenichiro Muraoka, Takashi Agari, Masahiro Kameda, Takashi Uozumi, Naoki Tajiri, Takamasa Morimoto, Meng Jing, Tanefumi Baba, Feifei Wang, Hanbai Leung, Toshihiro Matsui, Yasuyuki Miyoshi, Isao Date |
| Abstract |
Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-2-pyrazolin-5-one), which has already been used for the treatment of cerebral ischemia in Japan, on TH-positive dopaminergic neurons using PD model both in vitro and in vivo. 6-hydroxydopamine (6-OHDA), a neurotoxin for dopaminergic neurons, was added to cultured dopaminergic neurons derived from murine embryonal ventral mesencephalon with subsequet administration of edaravone or saline. The number of surviving TH-positive neurons and the degree of cell damage induced by free radicals were analyzed. In parallel, edaravone or saline was intravenously administered for PD model of rats receiving intrastriatal 6-OHDA lesion with subsequent behavioral and histological analyses. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 2% |
| Japan | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 58 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 20% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Postgraduate | 8 | 13% |
| Student > Master | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Other | 17 | 28% |
| Unknown | 4 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 34% |
| Agricultural and Biological Sciences | 15 | 25% |
| Chemistry | 5 | 8% |
| Neuroscience | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 9 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2017.
All research outputs
#3,732,312
of 22,789,566 outputs
Outputs from BMC Neuroscience
#165
of 1,244 outputs
Outputs of similar age
#12,868
of 82,265 outputs
Outputs of similar age from BMC Neuroscience
#2
of 10 outputs
Altmetric has tracked 22,789,566 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,244 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.