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Mendeley readers
Attention Score in Context
| Title |
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
|
|---|---|
| Published in |
Journal of Hematology & Oncology, April 2011
|
| DOI | 10.1186/1756-8722-4-13 |
| Pubmed ID | |
| Authors |
Shinichiro Takahashi |
| Abstract |
FLT3 is a type III receptor tyrosine kinase. Mutations of FLT3 comprise one of the most frequently identified types of genetic alterations in acute myeloid leukemia. One-third of acute myeloid leukemia patients have mutations of this gene, and the majority of these mutations involve an internal tandem duplication in the juxtamembrane region of FLT3, leading to constitutive activation of downstream signaling pathways and aberrant cell growth. This review summarizes the current understanding of the effects of the downstream molecular signaling pathways after FLT3 activation, with a particular focus on the effects on transcription factors. Moreover, this review describes novel FLT3-targeted therapies, as well as efficient combination therapies for FLT3-mutated leukemia cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 289 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| Belarus | 1 | <1% |
| Unknown | 285 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 21% |
| Student > Bachelor | 47 | 16% |
| Researcher | 44 | 15% |
| Student > Master | 34 | 12% |
| Student > Doctoral Student | 15 | 5% |
| Other | 36 | 12% |
| Unknown | 53 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 74 | 26% |
| Biochemistry, Genetics and Molecular Biology | 70 | 24% |
| Medicine and Dentistry | 52 | 18% |
| Immunology and Microbiology | 12 | 4% |
| Chemistry | 12 | 4% |
| Other | 16 | 6% |
| Unknown | 53 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#2,134,050
of 24,907,378 outputs
Outputs from Journal of Hematology & Oncology
#174
of 1,273 outputs
Outputs of similar age
#8,835
of 114,265 outputs
Outputs of similar age from Journal of Hematology & Oncology
#2
of 5 outputs
Altmetric has tracked 24,907,378 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.