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Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities

Overview of attention for article published in Journal of Neuroinflammation, August 2006
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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1 Wikipedia page

Citations

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8 Dimensions

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16 Mendeley
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Title
Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities
Published in
Journal of Neuroinflammation, August 2006
DOI 10.1186/1742-2094-3-19
Pubmed ID
Authors

Masumi Takano-Maruyama, Yoshiro Ohara, Kunihiko Asakura, Takako Okuwa

Abstract

Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. GDVII subgroup strains produce fatal poliomyelitis in mice without virus persistence or demyelination. In contrast, TO subgroup strains induce demyelinating disease with virus persistence in the spinal cords of weanling mice. Two proteins, whose open reading frames are located in the N-terminus of the polyprotein, recently have been reported to be important for TMEV biological activities. One is leader (L) protein and is processed from the most N-terminus of the polyprotein; its function is still unknown. Although the homology of capsid proteins between DA (a representative strain of TO subgroup) and GDVII strains is over 94% at the amino acid level, that of L shows only 85%. Therefore, L is thought to be a key protein for the subgroup-specific biological activities of TMEV. Various studies have demonstrated that L plays important roles in the escape of virus from host immune defenses in the early stage of infection. The second protein is a 17-18 kDa protein, L*, which is synthesized out-of-frame with the polyprotein. Only TO subgroup strains produce L* since GDVII subgroup strains have an ACG rather than AUG at the initiation site and therefore do not synthesize L*. 'Loss and gain of function' experiments demonstrate that L* is essential for virus growth in macrophages, a target cell for TMEV persistence. L* also has been demonstrated to be necessary for TMEV persistence and demyelination. Further analysis of L and L* will help elucidate the pathomechanism(s) of TMEV-induced demyelinating disease.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Bangladesh 1 6%
Germany 1 6%
Unknown 14 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 38%
Student > Ph. D. Student 4 25%
Student > Master 2 13%
Other 1 6%
Student > Bachelor 1 6%
Other 2 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 38%
Medicine and Dentistry 4 25%
Immunology and Microbiology 3 19%
Biochemistry, Genetics and Molecular Biology 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2010.
All research outputs
#815,335
of 3,616,176 outputs
Outputs from Journal of Neuroinflammation
#111
of 533 outputs
Outputs of similar age
#23,879
of 93,904 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 23 outputs
Altmetric has tracked 3,616,176 research outputs across all sources so far. This one has received more attention than most of these and is in the 62nd percentile.
So far Altmetric has tracked 533 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,904 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.