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Urinary miR-196a predicts disease progression in patients with chronic kidney disease

Overview of attention for article published in Journal of Translational Medicine, April 2018
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Title
Urinary miR-196a predicts disease progression in patients with chronic kidney disease
Published in
Journal of Translational Medicine, April 2018
DOI 10.1186/s12967-018-1470-2
Pubmed ID
Authors

Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen, Zhihong Liu

Abstract

Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney diseases. This study demonstrates that urinary miR-196a, a kidney-enriched miRNA, can predict progression of chronic kidney disease (CKD). Focal segmental glomerulosclerosis (FSGS) cohorts were used as the representative example of CKD. First, correlation of miR-196a with disease activity was analyzed using paired urine and plasma samples from FSGS patients with nephrotic-range proteinuria (FSGS-A), complete remission (FSGS-CR) and normal controls (NCs). Then, the value of urinary miR-196a in predicting disease progression was validated using another cohort of 231 FSGS patients who were followed-up until over 36 months or reaching end-stage renal disease (ESRD). MiR-196a levels were analyzed by quantitative reverse transcription-polymerase chain reaction. The results showed that urinary miR-196a significantly increased in FSGS-A compared with FSGS-CR and NCs, clearly distinguishing FSGS-A from FSGS-CR and NCs, whereas plasma miR-196a showed no difference among these groups. Moreover, urinary miR-196a, which was associated with proteinuria, estimated glomerular filtration rate (eGFR), interstitial fibrosis and tubular atrophy, significantly increased in patients progressed to ESRD compared to those not. Furthermore, patients with higher urinary miR-196a displayed poorer renal survival than those with lower urinary miR-196a. Multivariate Cox analysis confirmed urinary miR-196a as an independent risk factor for FSGS progression after adjusting for age, sex, proteinuria and eGFR. Prediction accuracy of ESRD was significantly improved by combining urinary miR-196a with other indicators including eGFR and proteinuria. Urinary miR-196a may serve as a biomarker for predicting CKD progression.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Professor 2 20%
Unspecified 2 20%
Student > Master 1 10%
Other 1 10%
Researcher 1 10%
Other 3 30%
Readers by discipline Count As %
Unspecified 3 30%
Medicine and Dentistry 3 30%
Agricultural and Biological Sciences 2 20%
Biochemistry, Genetics and Molecular Biology 1 10%
Design 1 10%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2018.
All research outputs
#11,379,202
of 12,793,889 outputs
Outputs from Journal of Translational Medicine
#2,433
of 2,523 outputs
Outputs of similar age
#239,123
of 274,098 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
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