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A “reverse pharmacology” approach for developing an anti-malarial phytomedicine

Overview of attention for article published in Malaria Journal, March 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

wikipedia
3 Wikipedia pages

Citations

dimensions_citation
58 Dimensions

Readers on

mendeley
112 Mendeley
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Title
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine
Published in
Malaria Journal, March 2011
DOI 10.1186/1475-2875-10-s1-s8
Pubmed ID
Authors

Merlin L Willcox, Bertrand Graz, Jacques Falquet, Chiaka Diakite, Sergio Giani, Drissa Diallo

Abstract

A "reverse pharmacology" approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of "reverse pharmacology" shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 <1%
Uganda 1 <1%
Indonesia 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Unknown 107 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 21%
Researcher 17 15%
Student > Master 16 14%
Other 9 8%
Student > Postgraduate 9 8%
Other 27 24%
Unknown 11 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 27%
Medicine and Dentistry 20 18%
Chemistry 17 15%
Pharmacology, Toxicology and Pharmaceutical Science 11 10%
Social Sciences 5 4%
Other 15 13%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2017.
All research outputs
#3,327,455
of 11,774,064 outputs
Outputs from Malaria Journal
#1,304
of 3,457 outputs
Outputs of similar age
#82,583
of 272,948 outputs
Outputs of similar age from Malaria Journal
#33
of 96 outputs
Altmetric has tracked 11,774,064 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,457 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.