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SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma

Overview of attention for article published in Journal of Cardiothoracic Surgery, April 2018
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Title
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
Published in
Journal of Cardiothoracic Surgery, April 2018
DOI 10.1186/s13019-018-0718-5
Pubmed ID
Authors

Ming-Chun Ma, Tai-Jan Chiu, Hung-I Lu, Wan-Ting Huang, Chien-Ming Lo, Wan-Yu Tien, Ya-Chun Lan, Yen-Yang Chen, Chang-Han Chen, Shau-Hsuan Li

Abstract

Sirtuin 1 (SIRT1) regulates DNA repair and metabolism by deacetylating target proteins. SIRT1 may be oncogenic because its overexpression has been detected in many cancers. The aim of the present study was to clarify the prognostic role of SIRT1 in patients with esophageal squamous cell carcinoma (ESCC) and evaluate the effect of SIRT1 inhibitor in vitro. The expression of SIRT1 was evaluated immunohistochemically in 155 surgically resected ESCC and the staining results were evaluated semiquantitatively by the Immunoreactive Scoring System. The clinical features and treatment outcome were analyzed. The effect of SIRT1 inhibitor, SIRT 1 inhibitor IV, (S)-35, was investigated in vitro on ESCC cell lines. The expression of SIRT1 on ESCC did not correlate with age, gender, tumor location, stage, T classification, N classification, surgical margin or histology. Univariate analysis showed that SIRT1 overexpression was associated with inferior overall survival (P = 0.004) and disease-free survival (P = 0.004). In multivariate comparison, SIRT1 overexpression remained independently associated with worse overall survival (P = 0.009, hazard ratio = 1.776) and disease-free survival (P = 0.017, hazard ratio = 1.642). In cell lines, SIRT1 inhibitor inhibited ESCC growth. Our study suggests that SIRT1 overexpression is an independent prognosticator for patients with ESCC and the SIRT1 inhibitor suppressed cell proliferation of ESCC cell lines. Our findings suggest that inhibition of SIRT1 signaling may be a promising novel target for ESCC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 25%
Student > Master 3 25%
Student > Bachelor 2 17%
Unspecified 2 17%
Other 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Unspecified 2 17%
Biochemistry, Genetics and Molecular Biology 1 8%
Chemistry 1 8%
Neuroscience 1 8%
Other 0 0%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2018.
All research outputs
#18,601,965
of 23,041,514 outputs
Outputs from Journal of Cardiothoracic Surgery
#646
of 1,246 outputs
Outputs of similar age
#255,537
of 329,244 outputs
Outputs of similar age from Journal of Cardiothoracic Surgery
#19
of 29 outputs
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So far Altmetric has tracked 1,246 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.