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Mendeley readers
Attention Score in Context
| Title |
Molecular action of methotrexate in inflammatory diseases
|
|---|---|
| Published in |
Arthritis Research & Therapy, March 2002
|
| DOI | 10.1186/ar419 |
| Pubmed ID | |
| Authors |
Edwin SL Chan, Bruce N Cronstein |
| Abstract |
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of inflammatory arthritis. Although methotrexate was first introduced as an antiproliferative agent that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti-inflammatory effects of methotrexate are mediated by adenosine. This nucleoside, acting at one or more of its receptors, is a potent endogenous anti-inflammatory mediator. In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate. |
Mendeley readers
The data shown below were compiled from readership statistics for 241 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Finland | 1 | <1% |
| Brazil | 1 | <1% |
| Romania | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 232 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 19% |
| Researcher | 38 | 16% |
| Student > Bachelor | 30 | 12% |
| Student > Master | 27 | 11% |
| Other | 18 | 7% |
| Other | 45 | 19% |
| Unknown | 37 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 80 | 33% |
| Agricultural and Biological Sciences | 33 | 14% |
| Biochemistry, Genetics and Molecular Biology | 24 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 7% |
| Chemistry | 11 | 5% |
| Other | 29 | 12% |
| Unknown | 46 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2014.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#1,710
of 3,381 outputs
Outputs of similar age
#42,929
of 127,718 outputs
Outputs of similar age from Arthritis Research & Therapy
#4
of 8 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,718 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.