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Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration

Overview of attention for article published in Cancer Cell International, September 2008
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Title
Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration
Published in
Cancer Cell International, September 2008
DOI 10.1186/1475-2867-8-13
Pubmed ID
Authors

Ahmed Yaqinuddin, Sohail A Qureshi, Romena Qazi, Farhat Abbas

Abstract

Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases (DNMTs) among which DNMT1 functions as a maintenance methylase while DNMT3a and 3b serve as de novo enzymes. Although DNMT3b has been shown to preferentially target the methylation of DNA sequences residing in pericentric heterochromatin whether it is involved in gene specific methylation remains an open question. To address this issue, we have silenced the expression of DNMT3b in the prostate-derived PC3 cells through RNA interference and subsequently studied the accompanied cellular changes as well as the expression profiles of selected genes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 4%
United States 1 4%
Germany 1 4%
Unknown 20 87%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 6 26%
Researcher 6 26%
Student > Ph. D. Student 4 17%
Student > Master 2 9%
Student > Bachelor 1 4%
Other 1 4%
Unknown 3 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 39%
Biochemistry, Genetics and Molecular Biology 4 17%
Medicine and Dentistry 4 17%
Social Sciences 1 4%
Arts and Humanities 1 4%
Other 0 0%
Unknown 4 17%