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Epigenetic and transcriptional determinants of the human breast

Overview of attention for article published in Nature Communications, February 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

news
3 news outlets
twitter
8 tweeters
patent
3 patents

Citations

dimensions_citation
25 Dimensions

Readers on

mendeley
125 Mendeley
Title
Epigenetic and transcriptional determinants of the human breast
Published in
Nature Communications, February 2015
DOI 10.1038/ncomms7351
Pubmed ID
Authors

Philippe Gascard, Misha Bilenky, Mahvash Sigaroudinia, Jianxin Zhao, Luolan Li, Annaick Carles, Allen Delaney, Angela Tam, Baljit Kamoh, Stephanie Cho, Malachi Griffith, Andy Chu, Gordon Robertson, Dorothy Cheung, Irene Li, Alireza Heravi-Moussavi, Michelle Moksa, Matthew Mingay, Angela Hussainkhel, Brad Davis, Raman P. Nagarajan, Chibo Hong, Lorigail Echipare, Henriette O’Geen, Matthew J. Hangauer, Jeffrey B. Cheng, Dana Neel, Donglei Hu, Michael T. McManus, Richard Moore, Andrew Mungall, Yussanne Ma, Patrick Plettner, Elad Ziv, Ting Wang, Peggy J. Farnham, Steven J.M. Jones, Marco A. Marra, Thea D. Tlsty, Joseph F. Costello, Martin Hirst

Abstract

While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we define a comprehensive human breast transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic retention events. Intersection of epigenetic states with RNA expression from distinct breast epithelium lineages demonstrates that mCpG provides a stable record of exonic and intronic usage, whereas H3K36me3 is dynamic. We find a striking asymmetry in epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Sweden 1 <1%
Italy 1 <1%
South Africa 1 <1%
Luxembourg 1 <1%
Norway 1 <1%
Australia 1 <1%
Korea, Republic of 1 <1%
Austria 1 <1%
Other 5 4%
Unknown 110 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 30%
Researcher 29 23%
Student > Master 15 12%
Other 10 8%
Professor > Associate Professor 7 6%
Other 27 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 50%
Biochemistry, Genetics and Molecular Biology 29 23%
Medicine and Dentistry 12 10%
Unspecified 9 7%
Engineering 2 2%
Other 10 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#429,582
of 11,987,888 outputs
Outputs from Nature Communications
#6,358
of 18,828 outputs
Outputs of similar age
#12,479
of 230,389 outputs
Outputs of similar age from Nature Communications
#198
of 603 outputs
Altmetric has tracked 11,987,888 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,828 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,389 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 603 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.