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Polymer Nanoparticles Mediated Codelivery of AntimiR-10b and AntimiR-21 for Achieving Triple Negative Breast Cancer Therapy

Overview of attention for article published in ACS Nano, February 2015
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Mentioned by

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2 tweeters

Citations

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105 Dimensions

Readers on

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109 Mendeley
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Title
Polymer Nanoparticles Mediated Codelivery of AntimiR-10b and AntimiR-21 for Achieving Triple Negative Breast Cancer Therapy
Published in
ACS Nano, February 2015
DOI 10.1021/nn507465d
Pubmed ID
Authors

Rammohan Devulapally, Narayana M. Sekar, Thillai V. Sekar, Kira Foygel, Tarik F. Massoud, Jürgen K. Willmann, Ramasamy Paulmurugan

Abstract

The current study shows the therapeutic outcome achieved in triple negative breast cancer (TNBC) by simultaneously antagonizing miR-21-induced antiapoptosis and miR-10b-induced metastasis, using antisense-miR-21-PS and antisense-miR-10b-PS delivered by polymer nanoparticles (NPs). We synthesized the antisense-miR-21 and antisense-miR-10b loaded PLGA-b-PEG polymer NPs and evaluated their cellular uptake, serum stability, release profile, and the subsequent synchronous blocking of endogenous miR-21 and miR-10b function in TNBC cells in culture, and tumor xenografts in living animals using molecular imaging. Results show that multitarget antagonization of endogenous miRNAs could be an efficient strategy for targeting metastasis and antiapoptosis in the treatment of metastatic cancer. Targeted delivery of antisense-miR-21 and antisense-miR-10b coloaded urokinase plasminogen activator receptor (uPAR) targeted polymer NPs treated mice showed substantial reduction in tumor growth at very low dose of 0.15 mg/kg, compared to the control NPs treated mice and 40% reduction in tumor growth compared to scramble peptide conjugated NPs treated mice, thus demonstrating a potential new therapeutic option for TNBC.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
India 1 <1%
Unknown 107 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 33%
Student > Master 18 17%
Researcher 13 12%
Student > Bachelor 8 7%
Student > Doctoral Student 6 6%
Other 13 12%
Unknown 15 14%
Readers by discipline Count As %
Chemistry 15 14%
Pharmacology, Toxicology and Pharmaceutical Science 15 14%
Medicine and Dentistry 14 13%
Agricultural and Biological Sciences 14 13%
Biochemistry, Genetics and Molecular Biology 13 12%
Other 18 17%
Unknown 20 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#5,168,040
of 9,780,262 outputs
Outputs from ACS Nano
#3,923
of 5,876 outputs
Outputs of similar age
#103,635
of 212,464 outputs
Outputs of similar age from ACS Nano
#133
of 215 outputs
Altmetric has tracked 9,780,262 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,876 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 215 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.