Title |
Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population
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Published in |
Genetics and Molecular Biology, June 2009
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DOI | 10.1590/s1415-47572009000200010 |
Pubmed ID | |
Authors |
Magaly B.P.L.V. Lima, Aldemir Branco de Oliveira-Filho, Júlia F. Campos, Fárida C.B.C. Melo, Washington Batista das Neves, Raul Antônio Morais Melo, José Alexandre Rodrigues Lemos |
Abstract |
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis. |
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