Title |
Developments in the scientific and clinical understanding of fibromyalgia
|
---|---|
Published in |
Arthritis Research & Therapy, October 2009
|
DOI | 10.1186/ar2720 |
Pubmed ID | |
Authors |
Dan Buskila |
Abstract |
Our understanding of fibromyalgia (FM) has made significant advances over the past decade. The current concept views FM as the result of central nervous system malfunction resulting in amplification of pain transmission and interpretation. Research done over the past years has demonstrated a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FM. Various external stimuli such as infection, trauma and stress may contribute to the development of the syndrome. The management of FM requires an integrated approach combining pharmacological and nonpharmacological modalities. The recent Food and Drugs Administration approval of pregabalin, duloxetine and milnacipran as medications for FM may herald a new era for the development of medications with higher specificity and efficacy for the condition. As our understanding of the biological basis and the genetic underpinning of FM increases, we hope to gain a better understanding of the true nature of the disorder, to better classify patients and to attain more rational therapeutic modalities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Israel | 2 | 1% |
New Zealand | 2 | 1% |
Bulgaria | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Norway | 1 | <1% |
Canada | 1 | <1% |
Other | 1 | <1% |
Unknown | 145 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 13% |
Student > Bachelor | 19 | 12% |
Student > Ph. D. Student | 17 | 11% |
Student > Doctoral Student | 17 | 11% |
Student > Master | 14 | 9% |
Other | 46 | 29% |
Unknown | 23 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 55 | 35% |
Psychology | 16 | 10% |
Nursing and Health Professions | 14 | 9% |
Agricultural and Biological Sciences | 14 | 9% |
Sports and Recreations | 6 | 4% |
Other | 24 | 15% |
Unknown | 28 | 18% |