Title |
Control of articular synovitis for bone and cartilage regeneration in rheumatoid arthritis
|
---|---|
Published in |
Inflammation and Regeneration, April 2018
|
DOI | 10.1186/s41232-018-0064-y |
Pubmed ID | |
Authors |
Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka, Shuichi Matsuda |
Abstract |
Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is essential to prevent joint destruction and achieve clinical remission. We have shown that not only achieving but also maintaining remission is crucial to prevent the progression of joint destruction. Although regeneration of the damaged joints is considered very rare, accumulating evidence shows that it actually occurs in routine clinical practice as a result of strong inhibition of synovitis using highly potent medications. Oral and intravenous medications affect the whole body, but to promote joint regeneration in a particular joint, two potent options are intra-articular steroid injection and synovectomy. In situations where strong inhibition of synovitis combined with self-regeneration cannot repair severe joint destruction, regenerative medicine may in the future play a crucial role in the regeneration of damaged joints. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Kenya | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 14% |
Student > Master | 4 | 14% |
Student > Bachelor | 3 | 11% |
Other | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Other | 4 | 14% |
Unknown | 9 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Business, Management and Accounting | 1 | 4% |
Other | 4 | 14% |
Unknown | 13 | 46% |