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Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

Overview of attention for article published in Retrovirology, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

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19 Dimensions

Readers on

mendeley
7 Mendeley
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Title
Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK
Published in
Retrovirology, January 2014
DOI 10.1186/1742-4690-11-40
Pubmed ID
Authors

Huihui Chong, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Xingxing Li, Yuxian He

Abstract

Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 such as T20 (Enfuvirtide) and C34 are potent viral fusion inhibitors. We have recently found that two N-terminal residues (Met115 and Thr116) of CHR peptides form a unique M-T hook structure that can greatly enhance the binding and anti-HIV activity of inhibitors. Here, we applied two M-T hook residues to optimize SC29EK, an electrostatically constrained peptide inhibitor with a potent anti-HIV activity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 29%
Student > Doctoral Student 1 14%
Student > Ph. D. Student 1 14%
Researcher 1 14%
Professor > Associate Professor 1 14%
Other 0 0%
Unknown 1 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 43%
Biochemistry, Genetics and Molecular Biology 2 29%
Chemistry 1 14%
Unknown 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2018.
All research outputs
#4,451,567
of 14,865,393 outputs
Outputs from Retrovirology
#267
of 855 outputs
Outputs of similar age
#65,730
of 216,132 outputs
Outputs of similar age from Retrovirology
#1
of 1 outputs
Altmetric has tracked 14,865,393 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 855 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them