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Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2015
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Title
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
Published in
Memórias do Instituto Oswaldo Cruz, February 2015
DOI 10.1590/0074-02760140260
Pubmed ID
Authors

Jaquelline Carla Valamiel de Oliveira-Silva, Girley Francisco Machado-de-Assis, Maykon Tavares Oliveira, Nívia Carolina Noguieira Paiva, Márcio Sobreira Silva Araújo, Cláudia Martins Carneiro, Olindo Assis Martins-Filho, Helen Rodrigues Martins, Marta de Lana

Abstract

Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 19%
Researcher 7 13%
Student > Postgraduate 5 9%
Student > Ph. D. Student 5 9%
Student > Bachelor 3 6%
Other 11 20%
Unknown 13 24%
Readers by discipline Count As %
Medicine and Dentistry 11 20%
Biochemistry, Genetics and Molecular Biology 8 15%
Agricultural and Biological Sciences 7 13%
Immunology and Microbiology 4 7%
Chemistry 3 6%
Other 8 15%
Unknown 13 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2015.
All research outputs
#11,127,491
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#759
of 862 outputs
Outputs of similar age
#180,145
of 216,937 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#8
of 10 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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