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In silico analysis suggests interaction between Ebola virus and the extracellular matrix

Overview of attention for article published in Frontiers in Microbiology, February 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

Citations

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19 Dimensions

Readers on

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58 Mendeley
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Title
In silico analysis suggests interaction between Ebola virus and the extracellular matrix
Published in
Frontiers in Microbiology, February 2015
DOI 10.3389/fmicb.2015.00135
Pubmed ID
Authors

Veljko Veljkovic, Sanja Glisic, Claude P. Muller, Matthew Scotch, Donald R. Branch, Vladimir R. Perovic, Milan Sencanski, Nevena Veljkovic, Alfonso Colombatti

Abstract

The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
India 1 2%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Student > Bachelor 9 16%
Student > Master 8 14%
Student > Ph. D. Student 6 10%
Other 5 9%
Other 9 16%
Unknown 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 22%
Biochemistry, Genetics and Molecular Biology 11 19%
Medicine and Dentistry 10 17%
Immunology and Microbiology 4 7%
Nursing and Health Professions 3 5%
Other 7 12%
Unknown 10 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2018.
All research outputs
#7,019,022
of 12,974,406 outputs
Outputs from Frontiers in Microbiology
#4,417
of 10,029 outputs
Outputs of similar age
#85,956
of 215,113 outputs
Outputs of similar age from Frontiers in Microbiology
#110
of 226 outputs
Altmetric has tracked 12,974,406 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,029 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,113 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 226 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.