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High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon

Overview of attention for article published in Parasites & Vectors, March 2018
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Title
High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
Published in
Parasites & Vectors, March 2018
DOI 10.1186/s13071-018-2787-7
Pubmed ID
Authors

Anne C. G. Almeida, Andrea Kuehn, Arthur J. M. Castro, Sheila Vitor-Silva, Erick F. G. Figueiredo, Larissa W. Brasil, Marcelo A. M. Brito, Vanderson S. Sampaio, Quique Bassat, Ingrid Felger, Wanderli P. Tadei, Wuelton M. Monteiro, Ivo Mueller, Marcus V. G. Lacerda

Abstract

Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (Pā€‰<ā€‰0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 26%
Student > Ph. D. Student 6 14%
Researcher 6 14%
Professor 4 9%
Other 4 9%
Other 4 9%
Unknown 8 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 5 12%
Immunology and Microbiology 5 12%
Agricultural and Biological Sciences 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 5 12%
Unknown 15 35%