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Searching for ancient balanced polymorphisms shared between Neanderthals and Modern Humans

Overview of attention for article published in Genetics and Molecular Biology, March 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 712)
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
45 Mendeley
Summary Blogs Twitter Dimensions citations
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Title
Searching for ancient balanced polymorphisms shared between Neanderthals and Modern Humans
Published in
Genetics and Molecular Biology, March 2018
DOI 10.1590/1678-4685-gmb-2017-0308
Pubmed ID
29658973
Authors

Lucas Henriques Viscardi, Vanessa Rodrigues Paixão-Côrtes, David Comas, Francisco Mauro Salzano, Diego Rovaris, Claiton Dotto Bau, Carlos Eduardo G. Amorim, Maria Cátira Bortolini

Abstract

Hominin evolution is characterized by adaptive solutions often rooted in behavioral and cognitive changes. If balancing selection had an important and long-lasting impact on the evolution of these traits, it can be hypothesized that genes associated with them should carry an excess of shared polymorphisms (trans- SNPs) across recent Homo species. In this study, we investigate the role of balancing selection in human evolution using available exomes from modern (Homo sapiens) and archaic humans (H. neanderthalensis and Denisovan) for an excess of trans-SNP in two gene sets: one associated with the immune system (IMMS) and another one with behavioral system (BEHS). We identified a significant excess of trans-SNPs in IMMS (N=547), of which six of these located within genes previously associated with schizophrenia. No excess of trans-SNPs was found in BEHS, but five genes in this system harbor potential signals for balancing selection and are associated with psychiatric or neurodevelopmental disorders. Our approach evidenced recent Homo trans-SNPs that have been previously implicated in psychiatric diseases such as schizophrenia, suggesting that a genetic repertoire common to the immune and behavioral systems could have been maintained by balancing selection starting before the split between archaic and modern humans.

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Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 16%
Student > Ph. D. Student 5 11%
Student > Bachelor 4 9%
Researcher 3 7%
Student > Doctoral Student 2 4%
Other 9 20%
Unknown 15 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 16%
Biochemistry, Genetics and Molecular Biology 6 13%
Psychology 4 9%
Neuroscience 3 7%
Medicine and Dentistry 2 4%
Other 4 9%
Unknown 19 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2020.
All research outputs
#3,300,371
of 23,043,346 outputs
Outputs from Genetics and Molecular Biology
#41
of 712 outputs
Outputs of similar age
#69,738
of 331,169 outputs
Outputs of similar age from Genetics and Molecular Biology
#3
of 15 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 712 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.

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