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Lobular breast cancer: incidence and genetic and non-genetic risk factors

Overview of attention for article published in Breast Cancer Research, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

twitter
17 tweeters
facebook
4 Facebook pages

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
214 Mendeley
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Title
Lobular breast cancer: incidence and genetic and non-genetic risk factors
Published in
Breast Cancer Research, March 2015
DOI 10.1186/s13058-015-0546-7
Pubmed ID
Authors

Laure Dossus, Patrick R Benusiglio

Abstract

While most invasive breast cancers consist of carcinomas of the ductal type, about 10% are invasive lobular carcinomas. Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobular carcinoma is more strongly associated with exposure to female hormones, and therefore its incidence is more subject to variation. This is illustrated by US figures during the 1987 to 2004 period: after 12 years of increases, breast cancer incidence declined steadily from 1999 to 2004, reflecting among other causes the decreasing use of menopausal hormone therapy, and these variations were stronger for invasive lobular than for invasive ductal carcinoma. Similarly, invasive lobular carcinoma is more strongly associated with early menarche, late menopause and late age at first birth. As for genetic risk factors, four high-penetrance genes are tested in clinical practice when genetic susceptibility to breast cancer is suspected, BRCA1, BRCA2, TP53 and CDH1. Germline mutations in BRCA1 and TP53 are predominantly associated with invasive ductal carcinoma, while BRCA2 mutations are associated with both ductal and lobular cancers. CDH1, the gene coding for the E-cadherin adhesion protein, is of special interest as mutations are associated with invasive lobular carcinoma, but never with ductal carcinoma. It was initially known as the main susceptibility gene for gastric cancer of the diffuse type, but the excess of breast cancers of the lobular type in CDH1 families led researchers to identify it also as a susceptibility gene for invasive lobular carcinoma. The risk of invasive lobular carcinoma is high in female mutation carriers, as about 50% are expected to develop the disease. Carriers must therefore undergo intensive breast cancer screening, with, for example, yearly magnetic resonance imaging and mammogram starting at age 30 years.

Twitter Demographics

The data shown below were collected from the profiles of 17 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Namibia 1 <1%
Spain 1 <1%
Japan 1 <1%
Unknown 208 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 42 20%
Student > Ph. D. Student 25 12%
Researcher 21 10%
Student > Bachelor 19 9%
Student > Doctoral Student 15 7%
Other 52 24%
Unknown 40 19%
Readers by discipline Count As %
Medicine and Dentistry 72 34%
Biochemistry, Genetics and Molecular Biology 35 16%
Agricultural and Biological Sciences 25 12%
Pharmacology, Toxicology and Pharmaceutical Science 8 4%
Nursing and Health Professions 6 3%
Other 20 9%
Unknown 48 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2019.
All research outputs
#1,557,539
of 15,625,110 outputs
Outputs from Breast Cancer Research
#194
of 1,641 outputs
Outputs of similar age
#27,111
of 219,293 outputs
Outputs of similar age from Breast Cancer Research
#1
of 1 outputs
Altmetric has tracked 15,625,110 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,641 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them