Title |
Highlights of glycosylation and adhesion related genes involved in myogenesis
|
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Published in |
BMC Genomics, July 2014
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DOI | 10.1186/1471-2164-15-621 |
Pubmed ID | |
Authors |
Vincent Grassot, Anne Da Silva, James Saliba, Abderrahman Maftah, Fabrice Dupuy, Jean-Michel Petit |
Abstract |
Myogenesis is initiated by myoblast differentiation and fusion to form myotubes and muscle fibres. A population of myoblasts, known as satellite cells, is responsible for post-natal growth of muscle and for its regeneration. This differentiation requires many changes in cell behaviour and its surrounding environment. These modifications are tightly regulated over time and can be characterized through the study of changes in gene expression associated with this process. During the initial myogenesis steps, using the myoblast cell line C2C12 as a model, Janot et al. (2009) showed significant variations in expression for genes involved in pathways of glycolipid synthesis. In this study we used murine satellite cells (MSC) and their ability to differentiate into myotubes or early fat storage cells to select glycosylation related genes whose variation of expression is myogenesis specific. |
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Mendeley readers
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