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Mendeley readers
Attention Score in Context
| Title |
The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis
|
|---|---|
| Published in |
Molecular Autism, March 2015
|
| DOI | 10.1186/s13229-015-0012-5 |
| Pubmed ID | |
| Authors |
Eriko Fujita-Jimbo, Yuko Tanabe, Zhiling Yu, Karin Kojima, Masato Mori, Hong Li, Sadahiko Iwamoto, Takanori Yamagata, Mariko Y Momoi, Takashi Momoi |
| Abstract |
Autism spectrum disorder (ASD) has a complex genetic etiology. Some symptoms and mutated genes, including neuroligin (NLGN), neurexin (NRXN), and SH3 and multiple ankyrin repeat domains protein (SHANK), are shared by schizophrenia and ASD. Little is known about the molecular pathogenesis of ASD. One of the possible molecular pathogenesis is an imbalance of excitatory and inhibitory receptors linked with the NLGN-PSD-95-SHANK complex via postsynaptic density protein/Drosophila disc large tumor suppressor/zonula occludens-1 protein (PDZ) binding. In the present study, we focused on GPR85 as a candidate gene for ASD because the C-terminal amino acid sequence of GPR85 [Thr-Cys-Val-Ile (YCVI)] is classified as a type II PDZ-binding motif, and GPR85 is a risk factor for schizophrenia. GPR85 is an orphan receptor that regulates neural and synaptic plasticity and modulates diverse behaviors, including learning and memory. While searching for molecules that associate with GPR85, we found that GPR85 was associated with postsynaptic density protein (PSD)-95 linked with NLGN in the brain. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Researcher | 15 | 18% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Student > Postgraduate | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 14 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 17% |
| Agricultural and Biological Sciences | 14 | 17% |
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Psychology | 7 | 8% |
| Medicine and Dentistry | 7 | 8% |
| Other | 10 | 12% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#15,351,826
of 25,654,806 outputs
Outputs from Molecular Autism
#593
of 722 outputs
Outputs of similar age
#139,006
of 277,366 outputs
Outputs of similar age from Molecular Autism
#10
of 14 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 722 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.