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In vivo antimicrobial activity of silver nanoparticles produced via a green chemistry synthesis using Acacia rigidula as a reducing and capping agent

Overview of attention for article published in International Journal of Nanomedicine, April 2018
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Mentioned by

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2 tweeters

Citations

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53 Dimensions

Readers on

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133 Mendeley
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Title
In vivo antimicrobial activity of silver nanoparticles produced via a green chemistry synthesis using <em>Acacia rigidula</em> as a reducing and capping agent
Published in
International Journal of Nanomedicine, April 2018
DOI 10.2147/ijn.s160605
Pubmed ID
Authors

Carlos Enrique Escárcega-González, Javier Alberto Garza-Cervantes, Augusto Vazquez-Rodríguez, Liliana Zulem Montelongo-Peralta, Mario Tadeo Treviño-Gonzalez, Enrique Díaz Barriga Castro, Esmeralda M Saucedo-Salazar, Rosa María Chávez Morales, Diana Ivette Regalado-Soto, Francisco Moises Treviño-González, Jose Luis Carrazco Rosales, Rocío Villalobos Cruz, Jose Ruben Morones-Ramirez

Abstract

One of the main issues in the medical field and clinical practice is the development of novel and effective treatments against infections caused by antibiotic-resistant bacteria. One avenue that has been approached to develop effective antimicrobials is the use of silver nanoparticles (Ag-NPs), since they have been found to exhibit an efficient and wide spectrum of antimicrobial properties. Among the main drawbacks of using Ag-NPs are their potential cytotoxicity against eukaryotic cells and the latent environmental toxicity of their synthesis methods. Therefore, diverse green synthesis methods, which involve the use of environmentally friendly plant extracts as reductive and capping agents, have become attractive to synthesize Ag-NPs that exhibit antimicrobial effects against resistant bacteria at concentrations below toxicity thresholds for eukaryotic cells. In this study, we report a green one-pot synthesis method that uses Acacia rigidula extract as a reducing and capping agent, to produce Ag-NPs with applications as therapeutic agents to treat infections in vivo. The Ag-NPs were characterized using transmission electron microscopy (TEM), high-resolution TEM, selected area electron diffraction, energy-dispersive spectroscopy, ultraviolet-visible, and Fourier transform infrared. We show that Ag-NPs are spherical with a narrow size distribution. The Ag-NPs show antimicrobial activities in vitro against Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and a clinical multidrug-resistant strain of P. aeruginosa) and Gram-positive (Bacillus subtilis) bacteria. Moreover, antimicrobial effects of the Ag-NPs, against a resistant P. aeruginosa clinical strain, were tested in a murine skin infection model. The results demonstrate that the Ag-NPs reported in this work are capable of eradicating pathogenic resistant bacteria in an infection in vivo. In addition, skin, liver, and kidney damage profiles were monitored in the murine infection model, and the results demonstrate that Ag-NPs can be used safely as therapeutic agents in animal models. Together, these results suggest the potential use of Ag-NPs, synthesized by green chemistry methods, as therapeutic agents against infections caused by resistant and nonresistant strains.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 133 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 14%
Student > Master 18 14%
Student > Ph. D. Student 18 14%
Researcher 12 9%
Student > Doctoral Student 7 5%
Other 29 22%
Unknown 30 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 15%
Chemistry 14 11%
Agricultural and Biological Sciences 13 10%
Chemical Engineering 8 6%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Other 31 23%
Unknown 39 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2018.
All research outputs
#8,188,289
of 13,573,940 outputs
Outputs from International Journal of Nanomedicine
#1,139
of 2,628 outputs
Outputs of similar age
#151,868
of 270,614 outputs
Outputs of similar age from International Journal of Nanomedicine
#16
of 44 outputs
Altmetric has tracked 13,573,940 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,628 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,614 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.