Title |
QTc interval screening for cardiac risk in methadone treatment of opioid dependence
|
---|---|
Published in |
Cochrane database of systematic reviews, June 2013
|
DOI | 10.1002/14651858.cd008939.pub2 |
Pubmed ID | |
Authors |
Pier Paolo Pani, Emanuela Trogu, Icro Maremmani, Matteo Pacini |
Abstract |
Methadone represents today the gold standard of efficacy for the pharmacological treatment of opioid dependence. Methadone, like many other medications, has been implicated in the prolongation of the rate-corrected QT (QTc) interval of the electrocardiogram (ECG), which is considered a marker for arrhythmias such as torsade de pointes (TdP). Indications on the association between methadone, even at therapeutic dosages, and TdP or sudden cardiac death have been reported. On these bases, consensus and recommendations involving QTc screening of patients receiving methadone treatment have been developed to identify patients with QTc above the thresholds considered at risk for cardiac arrhythmias, and they provide these individuals with alternative treatment (reduction of methadone dosage; provision of alternative opioid agonist treatment; treatment of associated risk factors). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 33% |
Ireland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | <1% |
Unknown | 169 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 25 | 15% |
Student > Master | 24 | 14% |
Student > Ph. D. Student | 16 | 9% |
Other | 13 | 8% |
Researcher | 9 | 5% |
Other | 30 | 18% |
Unknown | 53 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 64 | 38% |
Nursing and Health Professions | 15 | 9% |
Psychology | 12 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Agricultural and Biological Sciences | 5 | 3% |
Other | 14 | 8% |
Unknown | 54 | 32% |