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Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa

Overview of attention for article published in PLoS Neglected Tropical Diseases, March 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
twitter
19 tweeters
facebook
3 Facebook pages

Readers on

mendeley
41 Mendeley
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Title
Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa
Published in
PLoS Neglected Tropical Diseases, March 2015
DOI 10.1371/journal.pntd.0003631
Pubmed ID
Authors

Matthew H. Stremlau, Kristian G. Andersen, Onikepe A. Folarin, Jessica N. Grove, Ikponmwonsa Odia, Philomena E. Ehiane, Omowunmi Omoniwa, Omigie Omoregie, Pan-Pan Jiang, Nathan L. Yozwiak, Christian B. Matranga, Xiao Yang, Stephen K. Gire, Sarah Winnicki, Ridhi Tariyal, Stephen F. Schaffner, Peter O. Okokhere, Sylvanus Okogbenin, George O. Akpede, Danny A. Asogun, Dennis E. Agbonlahor, Peter J. Walker, Robert B. Tesh, Joshua Z. Levin, Robert F. Garry, Pardis C. Sabeti, Christian T. Happi, Charles E Rupprecht

Abstract

Next-generation sequencing (NGS) has the potential to transform the discovery of viruses causing unexplained acute febrile illness (UAFI) because it does not depend on culturing the pathogen or a priori knowledge of the pathogen's nucleic acid sequence. More generally, it has the potential to elucidate the complete human virome, including viruses that cause no overt symptoms of disease, but may have unrecognized immunological or developmental consequences. We have used NGS to identify RNA viruses in the blood of 195 patients with UAFI and compared them with those found in 328 apparently healthy (i.e., no overt signs of illness) control individuals, all from communities in southeastern Nigeria. Among UAFI patients, we identified the presence of nucleic acids from several well-characterized pathogenic viruses, such as HIV-1, hepatitis, and Lassa virus. In our cohort of healthy individuals, however, we detected the nucleic acids of two novel rhabdoviruses. These viruses, which we call Ekpoma virus-1 (EKV-1) and Ekpoma virus-2 (EKV-2), are highly divergent, with little identity to each other or other known viruses. The most closely related rhabdoviruses are members of the genus Tibrovirus and Bas-Congo virus (BASV), which was recently identified in an individual with symptoms resembling hemorrhagic fever. Furthermore, by conducting a serosurvey of our study cohort, we find evidence for remarkably high exposure rates to the identified rhabdoviruses. The recent discoveries of novel rhabdoviruses by multiple research groups suggest that human infection with rhabdoviruses might be common. While the prevalence and clinical significance of these viruses are currently unknown, these viruses could have previously unrecognized impacts on human health; further research to understand the immunological and developmental impact of these viruses should be explored. More generally, the identification of similar novel viruses in individuals with and without overt symptoms of disease highlights the need for a broader understanding of the human virome as efforts for viral detection and discovery advance.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Denmark 1 2%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 32%
Student > Master 9 22%
Researcher 8 20%
Student > Bachelor 6 15%
Other 3 7%
Other 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 34%
Medicine and Dentistry 9 22%
Biochemistry, Genetics and Molecular Biology 7 17%
Immunology and Microbiology 4 10%
Social Sciences 4 10%
Other 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2017.
All research outputs
#342,597
of 7,693,543 outputs
Outputs from PLoS Neglected Tropical Diseases
#413
of 4,188 outputs
Outputs of similar age
#14,532
of 208,620 outputs
Outputs of similar age from PLoS Neglected Tropical Diseases
#17
of 225 outputs
Altmetric has tracked 7,693,543 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,188 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 225 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.