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Anti-tumor properties of blackseed (Nigella sativa L.) extracts

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, April 2007
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Title
Anti-tumor properties of blackseed (Nigella sativa L.) extracts
Published in
Brazilian Journal of Medical and Biological Research, April 2007
DOI 10.1590/s0100-879x2006005000108
Pubmed ID
Authors

L. Ait Mbarek, H. Ait Mouse, N. Elabbadi, M. Bensalah, A. Gamouh, R. Aboufatima, A. Benharref, A. Chait, M. Kamal, A. Dalal, A. Zyad

Abstract

The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxic effect against the ICO1 cell line, with IC50 values ranging from 0.2 to 0.26% (v/v), tests on the BSR cell line revealed a high cytotoxic effect of the ethyl acetate extract (IC50 = 0.2%) compared to the essential oil (IC50 = 1.2%). These data show that the cytotoxicity of each extract depends on the tumor cell type. In vivo, using the DBA2/P815 (H2d) mouse model, our results clearly showed that the injection of the essential oil into the tumor site significantly inhibited solid tumor development. Indeed, on the 30th day of treatment, the tumor volume of the control animals was 2.5 +/- 0.6 cm(3), whereas the tumor volumes of the essential oil-treated animals were 0.22 +/- 0.1 and 0.16 +/- 0.1 cm(3) when the animals were injected with 30 microL (28.5 mg)/mouse and 50 microL (47.5 mg)/mouse per 48 h (six times), respectively. Interestingly, the administration of the essential oil into the tumor site inhibited the incidence of liver metastasis development and improved mouse survival.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Turkey 1 <1%
Malaysia 1 <1%
Indonesia 1 <1%
Pakistan 1 <1%
Morocco 1 <1%
India 1 <1%
Canada 1 <1%
Korea, Republic of 1 <1%
Other 1 <1%
Unknown 207 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 16%
Student > Bachelor 32 15%
Student > Master 30 14%
Researcher 19 9%
Student > Doctoral Student 15 7%
Other 43 20%
Unknown 43 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 20%
Medicine and Dentistry 34 16%
Biochemistry, Genetics and Molecular Biology 22 10%
Pharmacology, Toxicology and Pharmaceutical Science 21 10%
Chemistry 17 8%
Other 26 12%
Unknown 53 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#13,497,872
of 23,283,373 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#607
of 1,182 outputs
Outputs of similar age
#64,766
of 76,307 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#13
of 14 outputs
Altmetric has tracked 23,283,373 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,182 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,307 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.