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Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder

Overview of attention for article published in Neuropsychopharmacology, April 2018
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  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

5 tweeters
1 Facebook page


6 Dimensions

Readers on

26 Mendeley
Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder
Published in
Neuropsychopharmacology, April 2018
DOI 10.1038/s41386-018-0069-x
Pubmed ID

Amy C. Janes, Maya Zegel, Kyoko Ohashi, Jennifer Betts, Elena Molokotos, David Olson, Lauren Moran, Diego A. Pizzagalli


Nicotine dependence and major depressive disorder (MDD) are highly comorbid, yet causal links between these prevalent disorders are unclear. One possible mechanism is that nicotine ameliorates MDD-related neurobiological dysfunction in specific networks. For instance, cortico-striatal circuitry is enhanced by nicotine, and such paths are disrupted in individuals with MDD. Specifically, MDD has been associated with reduced connectivity between the nucleus accumbens (NAc) and rostral anterior cingulate cortex (rACC) but enhanced connectivity between the dorsal striatum (DS) and dorsolateral prefrontal cortex (DLPFC). Determining whether nicotine normalizes these circuits in non-smokers with MDD may elucidate mechanisms underlying links between disorders. This was tested by administering placebo and a 2-mg dose of nicotine to unmedicated non-smokers with and without MDD prior to collecting resting-state functional magnetic imaging data using a cross-over design. On placebo, individuals with MDD showed significantly reduced NAc-rACC and a trend for enhanced DS-DLPFC functional connectivity relative to healthy controls. In MDD, acute nicotine administration normalized both pathways to the level of healthy controls, while having no impact on healthy controls. Nicotine's effects on NAc-rACC connectivity was influenced by anhedonia, consistent with the role of this network in reward and nicotine's ability to enhance reward deficiencies in MDD. These results indicate that nicotine normalizes dysfunctional cortico-striatal communication in unmedicated non-smokers with MDD. Nicotine's influence on these circuitries highlights a possible mechanism whereby individuals with MDD are more vulnerable to develop nicotine dependence. Findings suggest that nicotinic agents may have therapeutic effects on disrupted cortico-striatal connectivity.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 15%
Researcher 3 12%
Student > Ph. D. Student 3 12%
Student > Postgraduate 2 8%
Professor 2 8%
Other 7 27%
Unknown 5 19%
Readers by discipline Count As %
Neuroscience 6 23%
Psychology 4 15%
Medicine and Dentistry 4 15%
Sports and Recreations 1 4%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 10 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2018.
All research outputs
of 15,049,257 outputs
Outputs from Neuropsychopharmacology
of 3,007 outputs
Outputs of similar age
of 276,482 outputs
Outputs of similar age from Neuropsychopharmacology
of 82 outputs
Altmetric has tracked 15,049,257 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,007 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.