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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
|
|---|---|
| Published in |
Nature Communications, April 2018
|
| DOI | 10.1038/s41467-018-03991-6 |
| Pubmed ID | |
| Authors |
Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May |
| Abstract |
The Pacific Northwest outbreak of cryptococcosis, caused by a near-clonal lineage of the fungal pathogen Cryptococcus gattii, represents the most significant cluster of life-threatening fungal infections in otherwise healthy human hosts currently known. The outbreak lineage has a remarkable ability to grow rapidly within human white blood cells, using a unique 'division of labour' mechanism within the pathogen population, where some cells adopt a dormant behaviour to support the growth of neighbouring cells. Here we demonstrate that pathogenic 'division of labour' can be triggered over large cellular distances and is mediated through the release of extracellular vesicles by the fungus. Isolated vesicles released by virulent strains are taken up by infected host macrophages and trafficked to the phagosome, where they trigger the rapid intracellular growth of non-outbreak fungal cells that would otherwise be eliminated by the host. Thus, long distance pathogen-to-pathogen communication via extracellular vesicles represents a novel mechanism to control complex virulence phenotypes in Cryptococcus gattii and, potentially, other infectious species. |
X Demographics
The data shown below were collected from the profiles of 105 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 25 | 24% |
| United States | 13 | 12% |
| France | 5 | 5% |
| Canada | 5 | 5% |
| Brazil | 3 | 3% |
| Netherlands | 3 | 3% |
| Austria | 1 | <1% |
| Germany | 1 | <1% |
| Thailand | 1 | <1% |
| Other | 14 | 13% |
| Unknown | 34 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 55 | 52% |
| Members of the public | 43 | 41% |
| Practitioners (doctors, other healthcare professionals) | 5 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 18% |
| Student > Master | 24 | 15% |
| Student > Bachelor | 24 | 15% |
| Researcher | 16 | 10% |
| Student > Doctoral Student | 10 | 6% |
| Other | 26 | 16% |
| Unknown | 30 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 21% |
| Biochemistry, Genetics and Molecular Biology | 31 | 20% |
| Immunology and Microbiology | 30 | 19% |
| Chemistry | 6 | 4% |
| Medicine and Dentistry | 5 | 3% |
| Other | 10 | 6% |
| Unknown | 43 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
All research outputs
#358,972
of 25,388,177 outputs
Outputs from Nature Communications
#5,624
of 56,791 outputs
Outputs of similar age
#8,171
of 340,997 outputs
Outputs of similar age from Nature Communications
#130
of 1,154 outputs
Altmetric has tracked 25,388,177 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,791 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,997 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,154 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.