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Low bone mineral density among HIV-infected patients in Brazil

Overview of attention for article published in Revista do Instituto de Medicina Tropical de São Paulo, December 2017
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Title
Low bone mineral density among HIV-infected patients in Brazil
Published in
Revista do Instituto de Medicina Tropical de São Paulo, December 2017
DOI 10.1590/s1678-9946201759089
Pubmed ID
Authors

Daniela Cardeal da Silva Chaba, Lisméia R. Soares, Rosa M. R. Pereira, George W. Rutherford, Tatiane Assone, Liliam Takayama, Luiz A. M. Fonseca, Alberto J. S. Duarte, Jorge Casseb

Abstract

Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in São Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients' medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/µL (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (≥ 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Doctoral Student 5 13%
Student > Master 5 13%
Student > Bachelor 4 10%
Researcher 4 10%
Other 7 18%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 8 21%
Immunology and Microbiology 4 10%
Nursing and Health Professions 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Sports and Recreations 2 5%
Other 8 21%
Unknown 12 31%