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Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect

Overview of attention for article published in Molecular Brain, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent

Citations

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27 Dimensions

Readers on

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77 Mendeley
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Title
Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect
Published in
Molecular Brain, March 2015
DOI 10.1186/s13041-015-0109-y
Pubmed ID
Authors

Gi Seok Jeong, Joon Young Chang, Ji Soo Park, Seung-A Lee, DoYeun Park, Junsung Woo, Heeyoung An, C Justin Lee, Sang-Hoon Lee

Abstract

In most animals, the nervous system consists of the central nervous system (CNS) and the peripheral nervous system (PNS), the latter of which connects the CNS to all parts of the body. Damage and/or malfunction of the nervous system causes serious pathologies, including neurodegenerative disorders, spinal cord injury, and Alzheimer's disease. Thus, not surprising, considerable research effort, both in vivo and in vitro, has been devoted to studying the nervous system and signal transmission through it. However, conventional in vitro cell culture systems do not enable control over diverse aspects of the neural microenvironment. Moreover, formation of certain nervous system growth patterns in vitro remains a challenge. In this study, we developed a deep hemispherical, microchannel-networked, concave array system and applied it to generate three-dimensional nerve-like neural bundles. The deep hemicylindrical channel network was easily fabricated by exploiting the meniscus induced by the surface tension of a liquid poly(dimethylsiloxane) (PDMS) prepolymer. Neurospheroids spontaneously aggregated in each deep concave microwell and were networked to neighboring spheroids through the deep hemicylindrical channel. Notably, two types of satellite spheroids also formed in deep hemispherical microchannels through self-aggregation and acted as an anchoring point to enhance formation of nerve-like networks with neighboring spheroids. During neural-network formation, neural progenitor cells successfully differentiated into glial and neuronal cells. These cells secreted laminin, forming an extracellular matrix around the host and satellite spheroids. Electrical stimuli were transmitted between networked neurospheroids in the resulting nerve-like neural bundle, as detected by imaging Ca(2+) signals in responding cells.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 76 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 21%
Student > Bachelor 13 17%
Researcher 12 16%
Student > Master 11 14%
Professor > Associate Professor 4 5%
Other 10 13%
Unknown 11 14%
Readers by discipline Count As %
Engineering 17 22%
Neuroscience 9 12%
Agricultural and Biological Sciences 8 10%
Medicine and Dentistry 7 9%
Biochemistry, Genetics and Molecular Biology 6 8%
Other 13 17%
Unknown 17 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2017.
All research outputs
#3,009,802
of 12,613,349 outputs
Outputs from Molecular Brain
#112
of 551 outputs
Outputs of similar age
#53,287
of 221,413 outputs
Outputs of similar age from Molecular Brain
#7
of 20 outputs
Altmetric has tracked 12,613,349 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 551 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,413 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.