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Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes

Overview of attention for article published in Molecular Brain, March 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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1 news outlet
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3 X users

Citations

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61 Dimensions

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115 Mendeley
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Title
Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes
Published in
Molecular Brain, March 2015
DOI 10.1186/s13041-015-0107-0
Pubmed ID
Authors

Alison Hamilton, Gerald W Zamponi, Stephen S G Ferguson

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects 36 million people worldwide, but currently has no effective treatment options. One of the original hallmarks of AD are plaques comprised of beta amyloid (Aβ) and neurofibrillary tangles comprised of phosphorylated Tau protein. However, it is soluble oligomeric Aβ which is more closely correlated with cognitive decline and is therefore considered to be the neurotoxic species. Oligomeric Aβ has recently been shown to form complexes with the glycosylphosphatidylinositol (GPI)-anchored membrane protein, cellular prion protein (PrP(c)), and these complexes are believed to play an important role in the progression of AD pathogenesis. Glutamate, the major excitatory neurotransmitter is responsible for mediating learning and memory under normal physiological conditions. However, the dysregulation of glutamatergic signaling has also been implicated in a number of neurodegenerative diseases including AD. Glutamate acts via both ionotropic glutamate receptors (iGluR) and metabotropic glutamate receptors (mGluR), each of which have been implicated in AD. There is now growing evidence to suggest that mGluR5 may contribute the AD pathogenesis by acting as scaffolds for the PrP(c)/Aβ oligomer complex, enabling the propagation of neurotoxic signaling in AD. In addition, PrP(c) and Aβ oligomer signaling via NMDARs may also contribute to AD pathology. The current review overviews our current understanding of the role of PrP(c) and Aβ oligomers in regulating glutamate receptor signaling, as well as highlights the importance of understanding these signaling complexes to develop more effective therapeutic strategies to treat AD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 114 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 28%
Researcher 20 17%
Student > Bachelor 11 10%
Student > Master 9 8%
Student > Doctoral Student 8 7%
Other 19 17%
Unknown 16 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 26%
Neuroscience 19 17%
Biochemistry, Genetics and Molecular Biology 19 17%
Medicine and Dentistry 8 7%
Chemistry 7 6%
Other 12 10%
Unknown 20 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#2,816,930
of 22,796,179 outputs
Outputs from Molecular Brain
#133
of 1,106 outputs
Outputs of similar age
#37,971
of 263,362 outputs
Outputs of similar age from Molecular Brain
#4
of 20 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,362 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.