Title |
Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
|
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Published in |
Molecular Neurodegeneration, April 2013
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DOI | 10.1186/1750-1326-8-14 |
Pubmed ID | |
Authors |
Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado |
Abstract |
Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic networks, and on their significant impact on the quality of life of PD patients. Herein, we performed a thorough behavioral analysis including motor, emotional and cognitive dimensions, of the unilateral medial forebrain bundle (MFB) 6-hydroxidopamine (6-OHDA)-lesioned model of PD, and further addressed the impact of pharmacological interventions with levodopa and antidepressants on mood dimensions. |
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United Kingdom | 1 | <1% |
Chile | 1 | <1% |
Spain | 1 | <1% |
France | 1 | <1% |
Unknown | 210 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 17% |
Student > Master | 33 | 15% |
Student > Bachelor | 26 | 12% |
Researcher | 25 | 12% |
Student > Doctoral Student | 13 | 6% |
Other | 30 | 14% |
Unknown | 51 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 44 | 21% |
Agricultural and Biological Sciences | 37 | 17% |
Medicine and Dentistry | 21 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 7% |
Biochemistry, Genetics and Molecular Biology | 12 | 6% |
Other | 22 | 10% |
Unknown | 62 | 29% |