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Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Overview of attention for article published in Nature Genetics, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
13 news outlets
blogs
8 blogs
policy
1 policy source
twitter
37 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

dimensions_citation
168 Dimensions

Readers on

mendeley
307 Mendeley
citeulike
4 CiteULike
Title
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Published in
Nature Genetics, March 2015
DOI 10.1038/ng.3246
Pubmed ID
Authors

Stacy Steinberg, Hreinn Stefansson, Thorlakur Jonsson, Hrefna Johannsdottir, Andres Ingason, Hannes Helgason, Patrick Sulem, Olafur Th Magnusson, Sigurjon A Gudjonsson, Unnur Unnsteinsdottir, Augustine Kong, Seppo Helisalmi, Hilkka Soininen, James J Lah, Dag Aarsland, Tormod Fladby, Ingun D Ulstein, Srdjan Djurovic, Sigrid B Sando, Linda R White, Gun-Peggy Knudsen, Lars T Westlye, Geir Selbæk, Ina Giegling, Harald Hampel, Mikko Hiltunen, Allan I Levey, Ole A Andreassen, Dan Rujescu, Palmi V Jonsson, Sigurbjorn Bjornsson, Jon Snaedal, Kari Stefansson

Abstract

We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12, P = 2.2 × 10(-13)) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8 × 10(-15)).

Twitter Demographics

The data shown below were collected from the profiles of 37 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 307 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Spain 2 <1%
United Kingdom 2 <1%
Italy 2 <1%
France 1 <1%
Switzerland 1 <1%
Japan 1 <1%
Norway 1 <1%
Germany 1 <1%
Other 2 <1%
Unknown 290 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 83 27%
Student > Ph. D. Student 73 24%
Student > Master 34 11%
Student > Bachelor 29 9%
Unspecified 22 7%
Other 66 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 114 37%
Biochemistry, Genetics and Molecular Biology 44 14%
Medicine and Dentistry 43 14%
Unspecified 41 13%
Neuroscience 31 10%
Other 34 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 186. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2016.
All research outputs
#70,899
of 13,318,687 outputs
Outputs from Nature Genetics
#198
of 6,187 outputs
Outputs of similar age
#1,602
of 221,485 outputs
Outputs of similar age from Nature Genetics
#7
of 79 outputs
Altmetric has tracked 13,318,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,485 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.