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Dry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood LeukocytesIn Vitro

Overview of attention for article published in Oxidative Medicine & Cellular Longetivity, January 2015
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  • Good Attention Score compared to outputs of the same age (74th percentile)

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6 tweeters
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2 Facebook pages

Citations

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11 Dimensions

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25 Mendeley
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Title
Dry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood LeukocytesIn Vitro
Published in
Oxidative Medicine & Cellular Longetivity, January 2015
DOI 10.1155/2015/762192
Pubmed ID
Authors

Dijana Žukovec Topalović, Lada Živković, Andrea Čabarkapa, Ninoslav Djelić, Vladan Bajić, Dragana Dekanski, Biljana Spremo-Potparević

Abstract

The thyroid hormones change the rate of basal metabolism, modulating the consumption of oxygen and causing production of reactive oxygen species, which leads to the development of oxidative stress and DNA strand breaks. Olive (Olea europaea L.) leaf contains many potentially bioactive compounds, making it one of the most potent natural antioxidants. The objective of this study was to evaluate the genotoxicity of L-thyroxine and to investigate antioxidative and antigenotoxic potential of the standardized oleuropein-rich dry olive leaf extract (DOLE) against hydrogen peroxide and L-thyroxine-induced DNA damage in human peripheral blood leukocytes by using the comet assay. Various concentrations of the extract were tested with both DNA damage inducers, under two different experimental conditions, pretreatment and posttreatment. Results indicate that L-thyroxine exhibited genotoxic effect and that DOLE displayed protective effect against thyroxine-induced genotoxicity. The number of cells with DNA damage, was significantly reduced, in both pretreated and posttreated samples (P < 0.05). Comparing the beneficial effect of all tested concentrations of DOLE, in both experimental protocols, it appears that extract was more effective in reducing DNA damage in the pretreatment, exhibiting protective role against L-thyroxine effect. This feature of DOLE can be explained by its capacity to act as potent free radical scavenger.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Researcher 3 12%
Professor 3 12%
Other 2 8%
Student > Master 2 8%
Other 4 16%
Unknown 6 24%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Pharmacology, Toxicology and Pharmaceutical Science 4 16%
Agricultural and Biological Sciences 4 16%
Chemistry 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 0 0%
Unknown 9 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2018.
All research outputs
#4,250,817
of 16,404,296 outputs
Outputs from Oxidative Medicine & Cellular Longetivity
#443
of 2,003 outputs
Outputs of similar age
#57,370
of 226,651 outputs
Outputs of similar age from Oxidative Medicine & Cellular Longetivity
#1
of 1 outputs
Altmetric has tracked 16,404,296 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,003 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,651 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them