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May Exercise Prevent Addiction?

Overview of attention for article published in Current Neuropharmacology, March 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#43 of 685)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

3 news outlets
1 tweeter
1 video uploader


27 Dimensions

Readers on

57 Mendeley
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May Exercise Prevent Addiction?
Published in
Current Neuropharmacology, March 2011
DOI 10.2174/157015911795017380
Pubmed ID

C. A. Fontes-Ribeiro, E. Marques, F. C. Pereira, A. P. Silva, T. R. A. Macedo


Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been demonstrated that exercise leads to an increase in the synthesis and release of dopamine, stimulates neuroplasticity and promotes feelings of well-being. Moreover, exercise and drugs of abuse activate overlapping neural systems. Thus, our aim was to study the influence of chronic exercise in the mechanism of addiction using an amphetamine-induced conditioned-place-preference in rats.Adult male Sprague-Dawley rats were randomly separated in groups with and without chronic exercise. Chronic exercise consisted in a 8 week treadmill running program, with increasing intensity. The conditioned place preference test was performed in both groups using a procedure and apparatus previously established. A 2 mg.kg(-1) amphetamine or saline solution was administered intraperitonially according to the schedule of the conditioned place preference. Before conditioning none of the animals showed preference for a specific compartment of the apparatus. The used amphetamine dose in the conditioning phase was able to produce a marked preference towards the drug-associated compartment in the group without exercise. In the animals with exercise a significant preference by the compartment associated with saline was observed. These results lead us to conclude that a previous practice of regular physical activity may help preventing amphetamine addiction in the conditions used in this test.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United States 1 2%
Sweden 1 2%
Unknown 54 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 21%
Researcher 11 19%
Student > Ph. D. Student 10 18%
Other 5 9%
Student > Bachelor 4 7%
Other 8 14%
Unknown 7 12%
Readers by discipline Count As %
Medicine and Dentistry 13 23%
Neuroscience 11 19%
Agricultural and Biological Sciences 10 18%
Psychology 5 9%
Nursing and Health Professions 2 4%
Other 7 12%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2020.
All research outputs
of 17,972,612 outputs
Outputs from Current Neuropharmacology
of 685 outputs
Outputs of similar age
of 232,614 outputs
Outputs of similar age from Current Neuropharmacology
of 11 outputs
Altmetric has tracked 17,972,612 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 685 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.