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Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme

Overview of attention for article published in Clinical Epigenetics, March 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)

Mentioned by

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10 tweeters

Citations

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24 Dimensions

Readers on

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29 Mendeley
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Title
Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme
Published in
Clinical Epigenetics, March 2015
DOI 10.1186/s13148-015-0075-3
Pubmed ID
Authors

Sara Weirich, Srikanth Kudithipudi, Ina Kycia, Albert Jeltsch

Abstract

Somatic mutations in epigenetic enzymes are frequently found in cancer tissues. The MLL3 H3K4-specific protein lysine monomethyltransferase is an important epigenetic enzyme, and it is among the most recurrently mutated enzymes in cancers. MLL3 mainly introduces H3K4me1 at enhancers. We investigated the enzymatic properties of MLL3 variants that carry somatic cancer mutations. Asn4848 is located at the cofactor binding sites, and the N4848S exchange renders the enzyme inactive. Tyr4884 is part of an aromatic pocket at the active center of the enzyme, and Y4884C converts MLL3 from a monomethyltransferase with substrate preference for H3K4me0 to a trimethyltransferase with H3K4me1 as preferred substrate. Expression of Y4884C leads to aberrant H3K4me3 formation in cells. Our data show that different somatic cancer mutations of MLL3 affect the enzyme activity in distinct and opposing manner highlighting the importance of experimentally studying the effects of somatic cancer mutations in key regulatory enzymes in order to develop and apply targeted tumor therapy.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 31%
Student > Master 5 17%
Student > Bachelor 3 10%
Researcher 3 10%
Student > Doctoral Student 2 7%
Other 4 14%
Unknown 3 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 38%
Agricultural and Biological Sciences 9 31%
Medicine and Dentistry 3 10%
Environmental Science 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2015.
All research outputs
#2,776,326
of 12,786,839 outputs
Outputs from Clinical Epigenetics
#151
of 603 outputs
Outputs of similar age
#48,310
of 221,455 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 3 outputs
Altmetric has tracked 12,786,839 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 603 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them