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ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.

Overview of attention for article published in Nature Communications, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
27 Mendeley
Title
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.
Published in
Nature Communications, January 2015
DOI 10.1038/ncomms7666
Pubmed ID
Authors

Koichi Miyatake, Morioh Kusakabe, Chika Takahashi, Eisuke Nishida, Miyatake, Koichi, Kusakabe, Morioh, Takahashi, Chika, Nishida, Eisuke

Abstract

Cilia are essential for embryogenesis and maintenance of homeostasis, but little is known about the signalling pathways that regulate ciliogenesis. Here, we identify ERK7, an atypical mitogen-activated protein kinase, as a key regulator of ciliogenesis. ERK7 is strongly expressed in ciliated tissues of Xenopus embryos. ERK7 knockdown markedly diminishes both the number and the length of cilia in multiciliated cells, and it inhibits the apical migration of basal bodies. Moreover, ERK7 knockdown results in a loss of the apical actin meshwork, which is required for the proper migration of basal bodies. We find that the actin regulator CapZIP, which has been shown to regulate ciliogenesis in a phosphorylation-dependent manner, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP through binding to both ERK7 and CapZIP. Collectively, these results identify an ERK7/Dishevelled/CapZIP axis that regulates ciliogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 41%
Student > Ph. D. Student 6 22%
Student > Master 4 15%
Professor 2 7%
Student > Bachelor 2 7%
Other 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 63%
Biochemistry, Genetics and Molecular Biology 6 22%
Unspecified 2 7%
Neuroscience 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2015.
All research outputs
#2,751,407
of 11,339,688 outputs
Outputs from Nature Communications
#11,185
of 16,887 outputs
Outputs of similar age
#57,520
of 207,720 outputs
Outputs of similar age from Nature Communications
#442
of 702 outputs
Altmetric has tracked 11,339,688 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 16,887 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 702 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.