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RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes

Overview of attention for article published in Journal of Hematology & Oncology, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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6 X users
patent
1 patent
facebook
1 Facebook page

Citations

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8 Dimensions

Readers on

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91 Mendeley
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Title
RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes
Published in
Journal of Hematology & Oncology, April 2015
DOI 10.1186/s13045-015-0127-3
Pubmed ID
Authors

Sean E Humphrey, Andrea L Kasinski

Abstract

From its discovery as an adaptive bacterial and archaea immune system, the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system has quickly been developed into a powerful and groundbreaking programmable nuclease technology for the global and precise editing of the genome in cells. This system allows for comprehensive unbiased functional studies and is already advancing the field by revealing genes that have previously unknown roles in disease processes. In this review, we examine and compare recently developed CRISPR-Cas platforms for global genome editing and examine the advancements these platforms have made in guide RNA design, guide RNA/Cas9 interaction, on-target specificity, and target sequence selection. We also explore some of the exciting therapeutic potentials of the CRISPR-Cas technology as well as some of the innovative new uses of this technology beyond genome editing.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Portugal 1 1%
Unknown 89 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 20%
Researcher 16 18%
Student > Ph. D. Student 14 15%
Student > Master 12 13%
Student > Postgraduate 7 8%
Other 17 19%
Unknown 7 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 42%
Biochemistry, Genetics and Molecular Biology 32 35%
Medicine and Dentistry 4 4%
Neuroscience 3 3%
Immunology and Microbiology 2 2%
Other 3 3%
Unknown 9 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2021.
All research outputs
#4,278,872
of 23,257,423 outputs
Outputs from Journal of Hematology & Oncology
#328
of 1,205 outputs
Outputs of similar age
#53,574
of 264,689 outputs
Outputs of similar age from Journal of Hematology & Oncology
#3
of 29 outputs
Altmetric has tracked 23,257,423 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,205 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.