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Anti-inflammatory and morphologic effects of pitavastatin on carotid arteries and thoracic aorta evaluated by integrated backscatter trans-esophageal ultrasound and PET/CT: a prospective randomized…

Overview of attention for article published in Cardiovascular Ultrasound, April 2015
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  • Good Attention Score compared to outputs of the same age (68th percentile)

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5 tweeters
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2 Facebook pages

Citations

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6 Dimensions

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31 Mendeley
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Title
Anti-inflammatory and morphologic effects of pitavastatin on carotid arteries and thoracic aorta evaluated by integrated backscatter trans-esophageal ultrasound and PET/CT: a prospective randomized comparative study with pravastatin (EPICENTRE study)
Published in
Cardiovascular Ultrasound, April 2015
DOI 10.1186/s12947-015-0012-9
Pubmed ID
Authors

Takatomo Watanabe, Masanori Kawasaki, Ryuhei Tanaka, Koji Ono, Nobuo Kako, Maki Saeki, Noriyuki Onishi, Maki Nagaya, Noriaki Sato, Hirotaka Miwa, Masazumi Arai, Toshiyuki Noda, Sachiro Watanabe, Shinya Minatoguchi

Abstract

We sought to evaluate the effects of a strong lipophilic statin (pitavastatin) on plaque components and morphology assessed by transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE), as well as plaque inflammation assessed by 18 F-fluorodeoxyglucose (FDG) PET/CT in the thoracic aorta and the carotid artery. Furthermore, we compared the effects of pitavastatin with those of mild hydrophilic statin (pravastatin). We examined atherosclerotic plaques in the thoracic aorta by TEE and those in the carotid artery by integrated backscatter (IBS)-TTE and PET/CT. We identified the target plaque, where there was macrophage infiltration and inflammation, by strong FDG uptake in the thoracic aorta and carotid arteries and measured maximum standard uptake values (max SUV) by PET/CT. We measured the intima-media thickness (IMT) and the corrected IBS (cIBS) values in the intima-media complex by TEE and TTE at the same site of FDG accumulation by PET/CT. Patients were randomly divided into two treatment groups: a pitavastatin group (PI group: n =10, 68.4 ± 5.1 years) and a pravastatin group (PR group: n =10, 63.9 ± 11.2 years). The same examinations were performed after six months at the same site in each patient. We used calculated target-to-background ratio (TBR) to measure max SUV of plaques and evaluated percent change of TBR. There was no significant difference in low density lipoprotein-cholesterol, TBR, IMT and cIBS values in plaques at baseline between the PI and PR groups. After treatment, there was greater improvement in TBR, cIBS values and IMT in the PI group than the PR group. The pravastatin treatment was less effective on plaque inflammation than pitavastatin treatment. This trend was the same in the carotid arteries and the thoracic aorta. Pitavastatin not only improved the atherosis as measured by IMT and cIBS values but also attenuated inflammation of plaques as measured by max SUV at the same site. The present study indicated that pitavastatin has stronger effects on the regression and stabilization of plaques in the thoracic aorta and carotid arteries compared with pravastatin.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Spain 1 3%
Netherlands 1 3%
Unknown 28 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Master 6 19%
Student > Bachelor 6 19%
Researcher 5 16%
Student > Doctoral Student 4 13%
Other 2 6%
Unknown 2 6%
Readers by discipline Count As %
Medicine and Dentistry 17 55%
Agricultural and Biological Sciences 3 10%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 2 6%
Social Sciences 1 3%
Other 1 3%
Unknown 5 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2015.
All research outputs
#4,590,754
of 15,340,060 outputs
Outputs from Cardiovascular Ultrasound
#62
of 266 outputs
Outputs of similar age
#69,405
of 226,104 outputs
Outputs of similar age from Cardiovascular Ultrasound
#1
of 1 outputs
Altmetric has tracked 15,340,060 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 266 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,104 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them