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Epigenome-wide association study of metabolic syndrome in African-American adults

Overview of attention for article published in Clinical Epigenetics, April 2018
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Title
Epigenome-wide association study of metabolic syndrome in African-American adults
Published in
Clinical Epigenetics, April 2018
DOI 10.1186/s13148-018-0483-2
Pubmed ID
Authors

Tomi Akinyemiju, Anh N. Do, Amit Patki, Stella Aslibekyan, Degui Zhi, Bertha Hidalgo, Hemant K. Tiwari, Devin Absher, Xin Geng, Donna K. Arnett, Marguerite R. Irvin

Abstract

The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constitute metabolic syndrome, a clinically defined condition highly prevalent among African-Americans. Identifying epigenetic alterations associated with metabolic syndrome may provide additional information regarding etiology beyond current evidence from genome-wide association studies. Data on metabolic syndrome and DNA methylation was assessed on 614 African-Americans from the Hypertension Genetic Epidemiology Network (HyperGEN) study. Metabolic syndrome was defined using the joint harmonized criteria, and DNA methylation was assessed using the Illumina HumanMethylation450K Bead Chip assay on DNA extracted from buffy coat. Linear mixed effects regression models were used to examine the association between CpG methylation at > 450,000 CpG sites and metabolic syndrome adjusted for study covariates. Replication using DNA from a separate sample of 69 African-Americans, as well as meta-analysis combining both cohorts, was conducted. Two differentially methylated CpG sites in the IGF2BP1 gene on chromosome 17 (cg06638433; p value = 3.10 × 10- 7) and the ABCG1 gene on chromosome 21 (cg06500161; p value = 2.60 × 10- 8) were identified. Results for the ABCG1 gene remained statistically significant in the replication dataset and meta-analysis. Metabolic syndrome was consistently associated with increased methylation in the ABCG1 gene in the discovery and replication datasets, a gene that encodes a protein in the ATP-binding cassette transporter family and is involved in intra- and extra-cellular signaling and lipid transport.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 36%
Lecturer 2 9%
Student > Doctoral Student 2 9%
Student > Master 2 9%
Professor 1 5%
Other 4 18%
Unknown 3 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 36%
Medicine and Dentistry 4 18%
Agricultural and Biological Sciences 3 14%
Computer Science 1 5%
Nursing and Health Professions 1 5%
Other 0 0%
Unknown 5 23%