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The Gut Microbiota Composition in Dichorionic Triplet Sets Suggests a Role for Host Genetic Factors

Overview of attention for article published in PLOS ONE, April 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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Title
The Gut Microbiota Composition in Dichorionic Triplet Sets Suggests a Role for Host Genetic Factors
Published in
PLOS ONE, April 2015
DOI 10.1371/journal.pone.0122561
Pubmed ID
Authors

Kiera Murphy, Carol Anne O’ Shea, C. Anthony Ryan, Eugene M. Dempsey, Paul W. O' Toole, Catherine Stanton, R. Paul Ross

Abstract

Monozygotic and dizygotic twin studies investigating the relative roles of host genetics and environmental factors in shaping gut microbiota composition have produced conflicting results. In this study, we investigated the gut microbiota composition of a healthy dichorionic triplet set. The dichorionic triplet set contained a pair of monozygotic twins and a fraternal sibling, with similar pre- and post-natal environmental conditions including feeding regime. V4 16S rRNA and rpoB amplicon pyrosequencing was employed to investigate microbiota composition, and the species and strain diversity of the culturable bifidobacterial population was also examined. At month 1, the monozygotic pair shared a similar microbiota distinct to the fraternal sibling. By month 12 however, the profile was more uniform between the three infants. Principal coordinate analysis (PCoA) of the microbiota composition revealed strong clustering of the monozygotic pair at month 1 and a separation of the fraternal infant. At months 2 and 3 the phylogenetic distance between the monozygotic pair and the fraternal sibling has greatly reduced and by month 12 the monozygotic pair no longer clustered separately from the fraternal infant. Pulse field gel electrophoresis (PFGE) analysis of the bifidobacterial population revealed a lack of strain diversity, with identical strains identified in all three infants at month 1 and 12. The microbiota of two antibiotic-treated dichorionic triplet sets was also investigated. Not surprisingly, in both triplet sets early life antibiotic administration appeared to be a major determinant of microbiota composition at month 1, irrespective of zygosity. By month 12, early antibiotic administration appeared to no longer exert such a strong influence on gut microbiota composition. We hypothesize that initially host genetics play a significant role in the composition of an individual's gut microbiota, unless an antibiotic intervention is given, but by month 12 environmental factors are the major determinant.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 87 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 22%
Student > Ph. D. Student 15 17%
Student > Master 13 15%
Student > Bachelor 6 7%
Student > Doctoral Student 5 6%
Other 15 17%
Unknown 15 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 22%
Medicine and Dentistry 18 20%
Biochemistry, Genetics and Molecular Biology 8 9%
Immunology and Microbiology 6 7%
Nursing and Health Professions 5 6%
Other 14 16%
Unknown 18 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#2,740,937
of 22,489,683 outputs
Outputs from PLOS ONE
#35,623
of 192,262 outputs
Outputs of similar age
#35,803
of 244,643 outputs
Outputs of similar age from PLOS ONE
#944
of 5,334 outputs
Altmetric has tracked 22,489,683 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 192,262 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5,334 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.