Chapter title |
IgE Immunotherapy Against Cancer.
|
---|---|
Chapter number | 6 |
Book title |
IgE Antibodies: Generation and Function
|
Published in |
Current topics in microbiology and immunology, January 2015
|
DOI | 10.1007/978-3-319-13725-4_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-913724-7, 978-3-31-913725-4, 978-3-31-913724-7, 978-3-31-913725-4
|
Authors |
Lai Sum Leoh, Tracy R Daniels-Wells, Manuel L Penichet, Leoh LS, Daniels-Wells TR, Penichet ML, Tracy R. Daniels-Wells, Manuel L. Penichet |
Abstract |
The success of antibody therapy in cancer is consistent with the ability of these molecules to activate immune responses against tumors. Experience in clinical applications, antibody design, and advancement in technology have enabled antibodies to be engineered with enhanced efficacy against cancer cells. This allows re-evaluation of current antibody approaches dominated by antibodies of the IgG class with a new light. Antibodies of the IgE class play a central role in allergic reactions and have many properties that may be advantageous for cancer therapy. IgE-based active and passive immunotherapeutic approaches have been shown to be effective in both in vitro and in vivo models of cancer, suggesting the potential use of these approaches in humans. Further studies on the anticancer efficacy and safety profile of these IgE-based approaches are warranted in preparation for translation toward clinical application. |
X Demographics
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Italy | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 25% |
Student > Bachelor | 11 | 19% |
Researcher | 8 | 14% |
Student > Master | 4 | 7% |
Student > Postgraduate | 3 | 5% |
Other | 4 | 7% |
Unknown | 13 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 25% |
Medicine and Dentistry | 9 | 16% |
Immunology and Microbiology | 8 | 14% |
Agricultural and Biological Sciences | 7 | 12% |
Engineering | 2 | 4% |
Other | 3 | 5% |
Unknown | 14 | 25% |