You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin
|
|---|---|
| Published in |
Genome Biology, April 2015
|
| DOI | 10.1186/s13059-015-0644-y |
| Pubmed ID | |
| Authors |
Amy R Vandiver, Rafael A Irizarry, Kasper D Hansen, Luis A Garza, Arni Runarsson, Xin Li, Anna L Chien, Timothy S Wang, Sherry G Leung, Sewon Kang, Andrew P Feinberg |
| Abstract |
Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans. We compare epidermis and dermis of both sun-protected and sun-exposed skin derived from younger subjects (under 35 years old) and older subjects (over 60 years old), using the Infinium HumanMethylation450 array and whole genome bisulfite sequencing. We observe large blocks of the genome that are hypomethylated in older, sun-exposed epidermal samples, with the degree of hypomethylation associated with clinical measures of photo-aging. We replicate these findings using whole genome bisulfite sequencing, comparing epidermis from an additional set of younger and older subjects. These blocks largely overlap known hypomethylated blocks in colon cancer and we observe that these same regions are similarly hypomethylated in squamous cell carcinoma samples. These data implicate large scale epigenomic change in mediating the effects of environmental damage with photo-aging. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 31% |
| United Kingdom | 2 | 15% |
| Canada | 2 | 15% |
| France | 1 | 8% |
| Spain | 1 | 8% |
| Unknown | 3 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 62% |
| Scientists | 3 | 23% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 133 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 22% |
| Researcher | 25 | 18% |
| Student > Master | 18 | 13% |
| Student > Bachelor | 11 | 8% |
| Professor | 6 | 4% |
| Other | 17 | 12% |
| Unknown | 30 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 26% |
| Agricultural and Biological Sciences | 30 | 22% |
| Medicine and Dentistry | 18 | 13% |
| Computer Science | 5 | 4% |
| Immunology and Microbiology | 3 | 2% |
| Other | 12 | 9% |
| Unknown | 33 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2023.
All research outputs
#1,513,180
of 25,576,801 outputs
Outputs from Genome Biology
#1,200
of 4,492 outputs
Outputs of similar age
#17,902
of 262,828 outputs
Outputs of similar age from Genome Biology
#15
of 65 outputs
Altmetric has tracked 25,576,801 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,492 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.