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The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer

Overview of attention for article published in Journal of Ovarian Research, April 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Readers on

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22 Mendeley
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Title
The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer
Published in
Journal of Ovarian Research, April 2015
DOI 10.1186/s13048-015-0143-5
Pubmed ID
Authors

Yingying Zhou, Min Wang, Jianlei Wu, Zhihui Jie, Shuang Chang, Ting Shuang

Abstract

We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. MicroRNA microarray was used to screen differentially expressed microRNAs between the chemosensitive and chemoresistant epithelial ovarian cancer tissues. RT-PCR was used to validate the candidate microRNA. The potential target genes and their enriched biological pathways of microRNA were also analyzed. Dual Luciferase Reporter Gene Assay was conducted to validate the regulation of miRNA-1307 on the 3'-UTR of DAPK3. miRNA-1307 was up-regulated in the chemoresistant epithelial ovarian cancer tissues compared to the chemosensitive counterparts. The up-regulation of miRNA-1307 was not associated with menopause, tumor differentiation state, clinical stage, and lymph node metastasis of ovarian cancer. Gene ontology analysis of miR-1307 candidate target genes indicated that miR-1307 candidate target genes were enriched in the processes of cell proliferation and differentiation, nucleotide synthesis and metabolism, and lymphocytes activation. Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Ph. D. Student 4 18%
Student > Bachelor 3 14%
Student > Master 2 9%
Student > Doctoral Student 1 5%
Other 0 0%
Unknown 6 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 45%
Agricultural and Biological Sciences 4 18%
Medicine and Dentistry 2 9%
Social Sciences 1 5%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2020.
All research outputs
#6,195,372
of 19,770,032 outputs
Outputs from Journal of Ovarian Research
#72
of 492 outputs
Outputs of similar age
#77,249
of 240,087 outputs
Outputs of similar age from Journal of Ovarian Research
#1
of 1 outputs
Altmetric has tracked 19,770,032 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 492 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them