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Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China

Overview of attention for article published in Diagnostic Pathology, April 2015
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Title
Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China
Published in
Diagnostic Pathology, April 2015
DOI 10.1186/s13000-015-0261-9
Pubmed ID
Authors

Ying-Ying Zheng, Xiang Xie, Yi-Tong Ma, Yi-Ning Yang, Zhen-Yan Fu, Xiao-Mei Li, Shuo Pan, Dilare Adi, Bang-Dang Chen, Fen Liu

Abstract

Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. However, There are unknown associations between the SNPs of C5aR1 gene and coronary artery disease (CAD). We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR1 gene for CAD using a case-control design, and determined the prevalence of C5aR1 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population. The rs10853784 was found to be associated with CAD in dominant model (CC vs TT + CT, P = 0.004). The difference remained statistically significant after multivariate adjustment (OR = 1.430, 95% CI: 1.087 ~ 1.882, P = 0.011). There was no significant difference in genotype distributions of rs4577202 and rs7250152 between CAD patients and control subjects. The frequency of the haplotype (A-T-C) was significantly higher in the CAD patients than in the controls (P = 0.035), and the haplotype (A-C-T) was significantly lower in the CAD patients than in the control subjects in Chinese Han population (P = 0.002). The results of this study indicate that rs10853784 of C5aR1 gene are associated with CAD in Han population of China, and A-C-T haplotypes may be protective genetic marker and the A-T-C may be risk genetic marker for CAD in Chinese Han population. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2054871241495194 .

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Professor 1 14%
Lecturer 1 14%
Student > Master 1 14%
Student > Postgraduate 1 14%
Other 1 14%
Readers by discipline Count As %
Medicine and Dentistry 3 43%
Agricultural and Biological Sciences 2 29%
Nursing and Health Professions 1 14%
Materials Science 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2015.
All research outputs
#7,812,605
of 12,450,849 outputs
Outputs from Diagnostic Pathology
#344
of 760 outputs
Outputs of similar age
#121,138
of 223,801 outputs
Outputs of similar age from Diagnostic Pathology
#22
of 27 outputs
Altmetric has tracked 12,450,849 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 760 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,801 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.