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Autism occurrence by MMR vaccine status among US children with older siblings with and without autism.

Overview of attention for article published in JAMA: Journal of the American Medical Association, April 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 19,494)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
248 Mendeley
Title
Autism occurrence by MMR vaccine status among US children with older siblings with and without autism.
Published in
JAMA: Journal of the American Medical Association, April 2015
DOI 10.1001/jama.2015.3077
Pubmed ID
Authors

Anjali Jain, Jaclyn Marshall, Ami Buikema, Tim Bancroft, Jonathan P. Kelly, Craig J. Newschaffer, Jain, Anjali, Marshall, Jaclyn, Buikema, Ami, Bancroft, Tim, Kelly, Jonathan P, Newschaffer, Craig J

Abstract

Despite research showing no link between the measles-mumps-rubella (MMR) vaccine and autism spectrum disorders (ASD), beliefs that the vaccine causes autism persist, leading to lower vaccination levels. Parents who already have a child with ASD may be especially wary of vaccinations. To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD. A retrospective cohort study using an administrative claims database associated with a large commercial health plan. Participants included children continuously enrolled in the health plan from birth to at least 5 years of age during 2001-2012 who also had an older sibling continuously enrolled for at least 6 months between 1997 and 2012. MMR vaccine receipt (0, 1, 2 doses) between birth and 5 years of age. ASD status defined as 2 claims with a diagnosis code in any position for autistic disorder or other specified pervasive developmental disorder (PDD) including Asperger syndrome, or unspecified PDD (International Classification of Diseases, Ninth Revision, Clinical Modification 299.0x, 299.8x, 299.9x). Of 95 727 children with older siblings, 994 (1.04%) were diagnosed with ASD and 1929 (2.01%) had an older sibling with ASD. Of those with older siblings with ASD, 134 (6.9%) had ASD, vs 860 (0.9%) children with unaffected siblings (P < .001). MMR vaccination rates (≥1 dose) were 84% (n = 78 564) at age 2 years and 92% (n = 86 063) at age 5 years for children with unaffected older siblings, vs 73% (n = 1409) at age 2 years and 86% (n = 1660) at age 5 years for children with affected siblings. MMR vaccine receipt was not associated with an increased risk of ASD at any age. For children with older siblings with ASD, at age 2, the adjusted relative risk (RR) of ASD for 1 dose of MMR vaccine vs no vaccine was 0.76 (95% CI, 0.49-1.18; P = .22), and at age 5, the RR of ASD for 2 doses compared with no vaccine was 0.56 (95% CI, 0.31-1.01; P = .052). For children whose older siblings did not have ASD, at age 2, the adjusted RR of ASD for 1 dose was 0.91 (95% CI, 0.67-1.20; P = .50) and at age 5, the RR of ASD for 2 doses was 1.12 (95% CI, 0.78-1.59; P = .55). In this large sample of privately insured children with older siblings, receipt of the MMR vaccine was not associated with increased risk of ASD, regardless of whether older siblings had ASD. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 248 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 15 6%
Italy 2 <1%
Canada 2 <1%
Germany 1 <1%
Saint Kitts and Nevis 1 <1%
Switzerland 1 <1%
Malaysia 1 <1%
Mexico 1 <1%
Ireland 1 <1%
Other 1 <1%
Unknown 222 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 55 22%
Student > Master 38 15%
Student > Ph. D. Student 33 13%
Researcher 33 13%
Student > Doctoral Student 31 13%
Other 58 23%
Readers by discipline Count As %
Medicine and Dentistry 93 38%
Agricultural and Biological Sciences 36 15%
Psychology 30 12%
Social Sciences 14 6%
Biochemistry, Genetics and Molecular Biology 11 4%
Other 64 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 3637. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#48
of 7,931,941 outputs
Outputs from JAMA: Journal of the American Medical Association
#4
of 19,494 outputs
Outputs of similar age
#4
of 204,422 outputs
Outputs of similar age from JAMA: Journal of the American Medical Association
#1
of 412 outputs
Altmetric has tracked 7,931,941 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,494 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,422 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 412 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.