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Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish

Overview of attention for article published in Genome Biology (Online Edition), April 2018
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)

Mentioned by

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5 tweeters

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38 Mendeley
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Title
Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish
Published in
Genome Biology (Online Edition), April 2018
DOI 10.1186/s13059-018-1428-y
Pubmed ID
Authors

Angel-Carlos Román, Julián Vicente-Page, Alfonso Pérez-Escudero, Jose M. Carvajal-González, Pedro M. Fernández-Salguero, Gonzalo G. de Polavieja

Abstract

Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influence of histone modifications on behavior. We find that laboratory and isogenic zebrafish larvae show consistent individual behaviors when swimming freely in identical wells or in reaction to stimuli. This behavioral inter-individual variability is reduced when we impair the histone deacetylation pathway. Individuals with high levels of histone H4 acetylation, and specifically H4K12, behave similarly to the average of the population, but those with low levels deviate from it. More precisely, we find a set of genomic regions whose histone H4 acetylation is reduced with the distance between the individual and the average population behavior. We find evidence that this modulation depends on a complex of Yin-yang 1 (YY1) and histone deacetylase 1 (HDAC1) that binds to and deacetylates these regions. These changes are not only maintained at the transcriptional level but also amplified, as most target regions are located near genes encoding transcription factors. We suggest that stochasticity in the histone deacetylation pathway participates in the generation of genetic-independent behavioral inter-individual variability.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Student > Ph. D. Student 8 21%
Student > Master 5 13%
Student > Bachelor 4 11%
Student > Doctoral Student 3 8%
Other 7 18%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 29%
Biochemistry, Genetics and Molecular Biology 11 29%
Neuroscience 5 13%
Environmental Science 2 5%
Social Sciences 2 5%
Other 1 3%
Unknown 6 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2018.
All research outputs
#7,501,091
of 14,221,435 outputs
Outputs from Genome Biology (Online Edition)
#2,690
of 3,154 outputs
Outputs of similar age
#121,291
of 275,236 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 1 outputs
Altmetric has tracked 14,221,435 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,154 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.8. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,236 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them