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Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma

Overview of attention for article published in Journal of Otolaryngology -- Head & Neck Surgery, April 2018
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Title
Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma
Published in
Journal of Otolaryngology -- Head & Neck Surgery, April 2018
DOI 10.1186/s40463-018-0273-z
Pubmed ID
Authors

Melody J. Xu, Tara J. Wu, Annemieke van Zante, Ivan H. El-Sayed, Alain P. Algazi, William R. Ryan, Patrick K. Ha, Sue S. Yom

Abstract

Management of locoregional recurrence (LRR) and distant metastasis (DM) in adenoid cystic carcinoma (ACC) is guided by limited data. We investigated mortality risks in patients diagnosed and treated for recurrent ACC. A retrospective review of ACC patients treated from 1989 to 2016 identified 36 patients with LRR or DM. High-risk disease was defined as skull base involvement (for LRR) or International Registry of Lung Metastases Group III/IV or extrapulmonary site of metastasis (for DM). Kaplan-Meier method, log-rank tests, and Cox proportional hazards were used for time-to-event analysis. Among 20 LRR and 16 DM patients, the median times to recurrence were 51 and 50 months, respectively. The median follow-up post-recurrence was 37.5 months (interquartile range (IQR)16.5-56.5). Post-recurrence 3-year overall survival (OS) was 78.5%, 73.3% for LRR and 85.1% for DM (p = 0.62). High-risk recurrences were associated with worse 3-year OS (68.8% for high-risk and 92.3% for low-risk, χ2 = 10.4, p = 0.001). Among LRR patients, 90% had surgery as part of their treatment. Multimodality therapy, age, and histopathologic features (size, margins, solid histology, lymphovascular or perineural invasion) were not associated with PFS or OS. High-risk LRR was the only variable associated with OS (χ2 = 5.9, p = 0.01). Among DM patients, six were initially managed with observation and ten received surgery, RT, or systemic therapy. Upfront therapy was not associated with improved PFS or OS. High-risk DM was the only variable associated with OS (χ2 = 4.7, p = 0.03). High-risk LRR and DM were associated with decreased 3-year OS. More effective therapies are needed for high-risk ACC recurrences.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Student > Master 3 15%
Other 2 10%
Researcher 2 10%
Student > Doctoral Student 1 5%
Other 4 20%
Unknown 4 20%
Readers by discipline Count As %
Medicine and Dentistry 7 35%
Biochemistry, Genetics and Molecular Biology 3 15%
Linguistics 1 5%
Social Sciences 1 5%
Agricultural and Biological Sciences 1 5%
Other 2 10%
Unknown 5 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2018.
All research outputs
#12,721,373
of 16,669,654 outputs
Outputs from Journal of Otolaryngology -- Head & Neck Surgery
#190
of 328 outputs
Outputs of similar age
#196,237
of 282,609 outputs
Outputs of similar age from Journal of Otolaryngology -- Head & Neck Surgery
#1
of 1 outputs
Altmetric has tracked 16,669,654 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 328 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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