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Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis

Overview of attention for article published in World Allergy Organization Journal, January 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)

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14 tweeters
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2 Facebook pages

Citations

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27 Dimensions

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52 Mendeley
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Title
Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis
Published in
World Allergy Organization Journal, January 2018
DOI 10.1186/s40413-018-0186-3
Pubmed ID
Authors

Enrico Heffler, Francesca Puggioni, Silvia Peveri, Marcello Montagni, Giorgio Walter Canonica, Giovanni Melioli

Abstract

Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the introduction of recombinant components in the test. More recently, microarrays of allergen components have significantly improved the ability to describe the IgE profile. Aim of this study was to evaluate the characteristics of the newly developed Allergy Explorer (ALEX), a macroarray containing both extracted "whole" allergens and molecular components. This method allows the acquisition of an IgE profile comprising 282 reagents (157 allergen extracts and 125 components), resulting in the widest screening of potential allergens available. Sera from 43 patients with allergies were assayed with ALEX and then with ImmunoCAP ISAC. The results of the two tests were compared, and the consistency of the molecular results with the presence of IgE in the relevant extract was also evaluated. A good correlation between ISAC and ALEX was observed. The ALEX results for second-level tests (i.e., specific IgE to complete extracted allergens) were consistent with the results obtained for the relevant components. Despite differences in the methodology, the IgE profiles detected for molecular allergens by ALEX and ISAC were very similar. The differences were mainly related to the lower dynamic range of ALEX and to the use of a CCD inhibitor in the first incubation phase, which reduced the binding of IgE to CCD, as represented in the extracted allergens and components. Based on our findings, ALEX is a novel tool for describing the IgE profile in a PM setting, where the IgE assay must be performed on many allergens and components. In particular, polysensitized patients and patients with pollen-food syndrome will have a real advantage due the combination of the second and third levels of allergy diagnostics in the same chip.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 15%
Student > Master 6 12%
Student > Doctoral Student 6 12%
Student > Ph. D. Student 5 10%
Student > Bachelor 5 10%
Other 15 29%
Unknown 7 13%
Readers by discipline Count As %
Medicine and Dentistry 12 23%
Biochemistry, Genetics and Molecular Biology 11 21%
Immunology and Microbiology 7 13%
Chemistry 3 6%
Agricultural and Biological Sciences 3 6%
Other 7 13%
Unknown 9 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2018.
All research outputs
#2,783,349
of 15,295,300 outputs
Outputs from World Allergy Organization Journal
#158
of 575 outputs
Outputs of similar age
#72,107
of 278,120 outputs
Outputs of similar age from World Allergy Organization Journal
#1
of 1 outputs
Altmetric has tracked 15,295,300 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 575 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,120 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them